DDX42 (DEAD-box helicase 42)

2007-04-01  

Identity

HGNC
DDX42
LOCATION
17q23.3
LOCUSID
11325
ALIAS
DDX42P,RHELP,RNAHP,SF3B8,SF3b125
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11325
MIM: 613369
HGNC: 18676
Ensembl: ENSG00000198231

Variants:

dbSNP: 11325
ClinVar: 11325
TCGA: ENSG00000198231
COSMIC: DDX42

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198231ENST00000359353Q86XP3
ENSG00000198231ENST00000389924Q86XP3
ENSG00000198231ENST00000457800A0A0A0MSJ0
ENSG00000198231ENST00000577940J3KRE3
ENSG00000198231ENST00000578137J3KTK9
ENSG00000198231ENST00000578681Q86XP3
ENSG00000198231ENST00000581135J3QRI2
ENSG00000198231ENST00000583590Q86XP3
ENSG00000198231ENST00000584261J3KRV0

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Spliceosome, U2-snRNPKEGGhsa_M00352
Spliceosome, U2-snRNPKEGGM00352
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
mRNA Splicing - Minor PathwayREACTOMER-HSA-72165

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
367972472023Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly.4
370942622023[The DEAD box RNA helicase DDX42 is an intrinsic inhibitor of positive-strand RNA viruses].0
367972472023Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly.4
370942622023[The DEAD box RNA helicase DDX42 is an intrinsic inhibitor of positive-strand RNA viruses].0
356522952022Cancer-associated mutations in SF3B1 disrupt the interaction between SF3B1 and DDX42.6
361614462022The DEAD box RNA helicase DDX42 is an intrinsic inhibitor of positive-strand RNA viruses.4
356522952022Cancer-associated mutations in SF3B1 disrupt the interaction between SF3B1 and DDX42.6
361614462022The DEAD box RNA helicase DDX42 is an intrinsic inhibitor of positive-strand RNA viruses.4
185889272008Interferon antagonist function of Japanese encephalitis virus NS4A and its interaction with DEAD-box RNA helicase DDX42.25
185889272008Interferon antagonist function of Japanese encephalitis virus NS4A and its interaction with DEAD-box RNA helicase DDX42.25
163972942006Ddx42p--a human DEAD box protein with RNA chaperone activities.27
163972942006Ddx42p--a human DEAD box protein with RNA chaperone activities.27
122349372002Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein.136
122349372002Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein.136

Citation

Dessen P

DDX42 (DEAD-box helicase 42)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47044/css/lib/favicon/js/web-card-gene.js