UBE2F (ubiquitin conjugating enzyme E2 F (putative))

2007-04-01  

Identity

HGNC
UBE2F
LOCATION
2q37.3
LOCUSID
140739
ALIAS
NCE2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 140739
MIM: 617700
HGNC: 12480
Ensembl: ENSG00000184182

Variants:

dbSNP: 140739
ClinVar: 140739
TCGA: ENSG00000184182
COSMIC: UBE2F

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000184182ENST00000272930Q969M7
ENSG00000184182ENST00000409332C9IZ93
ENSG00000184182ENST00000409633Q969M7
ENSG00000184182ENST00000409953Q969M7
ENSG00000184182ENST00000414443Q969M7
ENSG00000184182ENST00000416292C9JF62
ENSG00000184182ENST00000417231F2Z363
ENSG00000184182ENST00000433241Q969M7
ENSG00000184182ENST00000433568F8WB39
ENSG00000184182ENST00000434137C9JSK8
ENSG00000184182ENST00000434655C9J9P8
ENSG00000184182ENST00000439338G5E9R6
ENSG00000184182ENST00000439780F8WD80
ENSG00000184182ENST00000440223F8WFB7
ENSG00000184182ENST00000441728Q969M7
ENSG00000184182ENST00000445676F8WCT3
ENSG00000184182ENST00000448502C9JFD2
ENSG00000184182ENST00000454786F2Z363
ENSG00000184182ENST00000455999F8WDQ9
ENSG00000184182ENST00000612130Q969M7

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
347832262021NEDD8-conjugating enzyme E2 UBE2F confers radiation resistance by protecting lung cancer cells from apoptosis.6
347832262021NEDD8-conjugating enzyme E2 UBE2F confers radiation resistance by protecting lung cancer cells from apoptosis.6
331842732020Induction of NEDD8-conjugating enzyme E2 UBE2F by platinum protects lung cancer cells from apoptosis and confers to platinum-insensitivity.12
331842732020Induction of NEDD8-conjugating enzyme E2 UBE2F by platinum protects lung cancer cells from apoptosis and confers to platinum-insensitivity.12
299328982018UBE2M Is a Stress-Inducible Dual E2 for Neddylation and Ubiquitylation that Promotes Targeted Degradation of UBE2F.35
299328982018UBE2M Is a Stress-Inducible Dual E2 for Neddylation and Ubiquitylation that Promotes Targeted Degradation of UBE2F.35
275912662017Neddylation E2 UBE2F Promotes the Survival of Lung Cancer Cells by Activating CRL5 to Degrade NOXA via the K11 Linkage.62
275912662017Neddylation E2 UBE2F Promotes the Survival of Lung Cancer Cells by Activating CRL5 to Degrade NOXA via the K11 Linkage.62
232012712013Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes.64
232012712013Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes.64

Citation

Dessen P

UBE2F (ubiquitin conjugating enzyme E2 F (putative))

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47077