Identity
HGNC
LOCATION
3p14.1
LOCUSID
ALIAS
NAE2,UBE1C,hUBA3
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9039
MIM: 603172
HGNC: 12470
Ensembl: ENSG00000144744
Variants:
dbSNP: 9039
ClinVar: 9039
TCGA: ENSG00000144744
COSMIC: UBA3
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38298057 | 2024 | UBA3 promotes the occurrence and metastasis of intrahepatic cholangiocarcinoma through MAPK signaling pathway. | 0 |
| 38298057 | 2024 | UBA3 promotes the occurrence and metastasis of intrahepatic cholangiocarcinoma through MAPK signaling pathway. | 0 |
| 37656220 | 2023 | The NEDD8-activating enzyme E1 UBA3 orchestrates the immunosuppressive microenvironment in lung adenocarcinoma via the NF-кB pathway. | 2 |
| 37668436 | 2023 | UBE1C is upregulated and promotes neddylation of p53 in lung cancer. | 1 |
| 37656220 | 2023 | The NEDD8-activating enzyme E1 UBA3 orchestrates the immunosuppressive microenvironment in lung adenocarcinoma via the NF-кB pathway. | 2 |
| 37668436 | 2023 | UBE1C is upregulated and promotes neddylation of p53 in lung cancer. | 1 |
| 24525735 | 2014 | Suppression of tumor angiogenesis by targeting the protein neddylation pathway. | 41 |
| 24691136 | 2014 | Mutations in UBA3 confer resistance to the NEDD8-activating enzyme inhibitor MLN4924 in human leukemic cells. | 26 |
| 25229838 | 2014 | Neddylation pathway is up-regulated in human intrahepatic cholangiocarcinoma and serves as a potential therapeutic target. | 43 |
| 24525735 | 2014 | Suppression of tumor angiogenesis by targeting the protein neddylation pathway. | 41 |
| 24691136 | 2014 | Mutations in UBA3 confer resistance to the NEDD8-activating enzyme inhibitor MLN4924 in human leukemic cells. | 26 |
| 25229838 | 2014 | Neddylation pathway is up-regulated in human intrahepatic cholangiocarcinoma and serves as a potential therapeutic target. | 43 |
| 22821745 | 2012 | E2-binding surface on Uba3 β-grasp domain undergoes a conformational transition. | 1 |
| 22821745 | 2012 | E2-binding surface on Uba3 β-grasp domain undergoes a conformational transition. | 1 |
| 18652489 | 2008 | Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD8's E1. | 27 |
Citation
Dessen P
UBA3 (ubiquitin like modifier activating enzyme 3)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/47097/uba3
