AKAP1 (A-kinase anchoring protein 1)

2007-04-01  

Identity

HGNC
AKAP1
LOCATION
17q22
LOCUSID
8165
ALIAS
AKAP,AKAP121,AKAP149,AKAP84,D-AKAP1,PPP1R43,PRKA1,SAKAP84,TDRD17
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8165
MIM: 602449
HGNC: 367
Ensembl: ENSG00000121057

Variants:

dbSNP: 8165
ClinVar: 8165
TCGA: ENSG00000121057
COSMIC: AKAP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000121057ENST00000314126Q92667
ENSG00000121057ENST00000337714Q92667
ENSG00000121057ENST00000337714A0A140VK05
ENSG00000121057ENST00000481416Q92667
ENSG00000121057ENST00000539273Q92667
ENSG00000121057ENST00000539273A0A140VK05
ENSG00000121057ENST00000570423A0A0G2JLF7
ENSG00000121057ENST00000571629Q92667
ENSG00000121057ENST00000571629A0A140VK05
ENSG00000121057ENST00000572156I3L2A2
ENSG00000121057ENST00000572557Q92667
ENSG00000121057ENST00000572557A0A140VK05
ENSG00000121057ENST00000572560I3L0V5
ENSG00000121057ENST00000572814I3L0K6
ENSG00000121057ENST00000573085I3L3L9
ENSG00000121057ENST00000573326I3NI36
ENSG00000121057ENST00000574683I3L364
ENSG00000121057ENST00000575032I3L3V6
ENSG00000121057ENST00000575186A0A0G2JLF7
ENSG00000121057ENST00000575322I3L2N7
ENSG00000121057ENST00000576295I3L0W0
ENSG00000121057ENST00000576591I3L3K1
ENSG00000121057ENST00000621116Q92667
ENSG00000121057ENST00000621116A0A140VK05

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382866482024AKAP1 in Renal Patients with AHF to Reduce Ferroptosis of Cardiomyocyte.0
382866482024AKAP1 in Renal Patients with AHF to Reduce Ferroptosis of Cardiomyocyte.0
371758192023AKAP1 Regulates Mitochondrial Dynamics during the Fatty-Acid-Promoted Maturation of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes as Indicated by Proteomics Sequencing.0
372966582023Role of A-Kinase Anchoring Protein 1 in Retinal Ganglion Cells: Neurodegeneration and Neuroprotection.2
371758192023AKAP1 Regulates Mitochondrial Dynamics during the Fatty-Acid-Promoted Maturation of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes as Indicated by Proteomics Sequencing.0
372966582023Role of A-Kinase Anchoring Protein 1 in Retinal Ganglion Cells: Neurodegeneration and Neuroprotection.2
324828932020A-kinase-anchoring protein 1 (dAKAP1)-based signaling complexes coordinate local protein synthesis at the mitochondrial surface.13
328552392020Induction of UCP1 and thermogenesis by a small molecule via AKAP1/PKA modulation.5
324828932020A-kinase-anchoring protein 1 (dAKAP1)-based signaling complexes coordinate local protein synthesis at the mitochondrial surface.13
328552392020Induction of UCP1 and thermogenesis by a small molecule via AKAP1/PKA modulation.5
305985072019Depletion of dAKAP1-protein kinase A signaling islands from the outer mitochondrial membrane alters breast cancer cell metabolism and motility.13
305985072019Depletion of dAKAP1-protein kinase A signaling islands from the outer mitochondrial membrane alters breast cancer cell metabolism and motility.13
285697812017Mitochondrial AKAP1 supports mTOR pathway and tumor growth.30
285697812017Mitochondrial AKAP1 supports mTOR pathway and tumor growth.30
268251242016Pivotal role of AKAP121 in mitochondrial physiology.13

Citation

Dessen P

AKAP1 (A-kinase anchoring protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47108/teaching-explorer/js/lib/cancer-prone-explorer/