PLEKHA8 (pleckstrin homology domain containing A8)

2007-04-01  

Identity

HGNC
PLEKHA8
LOCATION
7p14.3
LOCUSID
84725
ALIAS
FAPP2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84725
MIM: 608639
HGNC: 30037
Ensembl: ENSG00000106086

Variants:

dbSNP: 84725
ClinVar: 84725
TCGA: ENSG00000106086
COSMIC: PLEKHA8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106086ENST00000258679Q96JA3
ENSG00000106086ENST00000396257Q96JA3
ENSG00000106086ENST00000396259B5MDU3
ENSG00000106086ENST00000440706Q96JA3
ENSG00000106086ENST00000440706A0A2P1JJM6
ENSG00000106086ENST00000449726Q96JA3
ENSG00000106086ENST00000449726A0A2P1JJM6
ENSG00000106086ENST00000622102A0A087X1S6
ENSG00000106086ENST00000649443A0A3B3IST3

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
PI MetabolismREACTOMER-HSA-1483255
Synthesis of PIPs at the plasma membraneREACTOMER-HSA-1660499

References

Pubmed IDYearTitleCitations
347965182022Downregulation of FAPP2 gene induces cell autophagy and inhibits PI3K/AKT/mTOR pathway in T-cell acute lymphoblastic leukemia.2
347965182022Downregulation of FAPP2 gene induces cell autophagy and inhibits PI3K/AKT/mTOR pathway in T-cell acute lymphoblastic leukemia.2
320453592020miR-98 is involved in missed abortion by targeting GDF6 and FAPP2.7
329143612020Phosphatidylinositol 4-phosphate adaptor protein 2 accelerates the proliferation and invasion of hepatocellular carcinoma cells by enhancing Wnt/β-catenin signaling.3
333899032020FAPP2 Accelerates the Proliferation and Invasion of Hepatocellular Carcinoma Cells via Wnt/β-Catenin Signaling.2
320453592020miR-98 is involved in missed abortion by targeting GDF6 and FAPP2.7
329143612020Phosphatidylinositol 4-phosphate adaptor protein 2 accelerates the proliferation and invasion of hepatocellular carcinoma cells by enhancing Wnt/β-catenin signaling.3
333899032020FAPP2 Accelerates the Proliferation and Invasion of Hepatocellular Carcinoma Cells via Wnt/β-Catenin Signaling.2
304084642019FAPP2 promotes tumor cell growth in human colon cancer through activation of Wnt signaling.5
304084642019FAPP2 promotes tumor cell growth in human colon cancer through activation of Wnt signaling.5
302061202018Structural analyses of 4-phosphate adaptor protein 2 yield mechanistic insights into sphingolipid recognition by the glycolipid transfer protein family.6
302061202018Structural analyses of 4-phosphate adaptor protein 2 yield mechanistic insights into sphingolipid recognition by the glycolipid transfer protein family.6
251227792014Modulation of hepatitis C virus genome replication by glycosphingolipids and four-phosphate adaptor protein 2.52
251227792014Modulation of hepatitis C virus genome replication by glycosphingolipids and four-phosphate adaptor protein 2.52
222660152012Connecting vesicular transport with lipid synthesis: FAPP2.13

Citation

Dessen P

PLEKHA8 (pleckstrin homology domain containing A8)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47128/teaching-explorer/css/lib/haematological-explorer/