Identity
HGNC
LOCATION
9q33.2
LOCUSID
ALIAS
FBW2,Fwd2,Md6
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 26190
MIM: 609071
HGNC: 13608
Ensembl: ENSG00000119402
Variants:
dbSNP: 26190
ClinVar: 26190
TCGA: ENSG00000119402
COSMIC: FBXW2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000119402 | ENST00000453291 | Q4VXH1 |
| ENSG00000119402 | ENST00000608872 | Q9UKT8 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37736741 | 2023 | FBXW2 suppresses breast tumorigenesis by targeting AKT-Moesin-SKP2 axis. | 2 |
| 37736741 | 2023 | FBXW2 suppresses breast tumorigenesis by targeting AKT-Moesin-SKP2 axis. | 2 |
| 35499593 | 2022 | FBXW2 inhibits prostate cancer proliferation and metastasis via promoting EGFR ubiquitylation and degradation. | 10 |
| 35499593 | 2022 | FBXW2 inhibits prostate cancer proliferation and metastasis via promoting EGFR ubiquitylation and degradation. | 10 |
| 33962073 | 2021 | TAK1 Is a Novel Target in Hepatocellular Carcinoma and Contributes to Sorafenib Resistance. | 11 |
| 33962073 | 2021 | TAK1 Is a Novel Target in Hepatocellular Carcinoma and Contributes to Sorafenib Resistance. | 11 |
| 30918250 | 2019 | FBXW2 suppresses migration and invasion of lung cancer cells via promoting β-catenin ubiquitylation and degradation. | 48 |
| 31548378 | 2019 | The FBXW2-MSX2-SOX2 axis regulates stem cell property and drug resistance of cancer cells. | 46 |
| 30918250 | 2019 | FBXW2 suppresses migration and invasion of lung cancer cells via promoting β-catenin ubiquitylation and degradation. | 48 |
| 31548378 | 2019 | The FBXW2-MSX2-SOX2 axis regulates stem cell property and drug resistance of cancer cells. | 46 |
| 28090088 | 2017 | The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor. | 47 |
| 28090088 | 2017 | The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor. | 47 |
| 23651062 | 2013 | RACK1 (receptor for activated C-kinase 1) interacts with FBW2 (F-box and WD-repeat domain-containing 2) to up-regulate GCM1 (glial cell missing 1) stability and placental cell migration and invasion. | 12 |
| 23651062 | 2013 | RACK1 (receptor for activated C-kinase 1) interacts with FBW2 (F-box and WD-repeat domain-containing 2) to up-regulate GCM1 (glial cell missing 1) stability and placental cell migration and invasion. | 12 |
| 18703417 | 2008 | Ubiquitin-conjugating enzyme UBE2D2 is responsible for FBXW2 (F-box and WD repeat domain containing 2)-mediated human GCM1 (glial cell missing homolog 1) ubiquitination and degradation. | 13 |
Citation
Dessen P
FBXW2 (F-box and WD repeat domain containing 2)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/47148/fbxw2
