NR2F2 (nuclear receptor subfamily 2 group F member 2)

2007-04-01  

Identity

HGNC
NR2F2
LOCATION
15q26.2
LOCUSID
7026
ALIAS
ARP-1,ARP1,CHTD4,COUPTF2,COUPTFB,COUPTFII,NF-E3,SRXX5,SVP40,TFCOUP2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7026
MIM: 107773
HGNC: 7976
Ensembl: ENSG00000185551

Variants:

dbSNP: 7026
ClinVar: 7026
TCGA: ENSG00000185551
COSMIC: NR2F2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185551ENST00000394166P24468
ENSG00000185551ENST00000394166F1D8R0
ENSG00000185551ENST00000394171P24468
ENSG00000185551ENST00000421109P24468
ENSG00000185551ENST00000453270P24468
ENSG00000185551ENST00000559679H3BTC2

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
Transcriptional regulation of white adipocyte differentiationREACTOMER-HSA-381340

References

Pubmed IDYearTitleCitations
370159192023An epigenetic switch controls an alternative NR2F2 isoform that unleashes a metastatic program in melanoma.4
370393672023Inflammation and DKK1-induced AKT activation contribute to endothelial dysfunction following NR2F2 loss.6
375007252023Heterozygous rare variants in NR2F2 cause a recognizable multiple congenital anomaly syndrome with developmental delays.4
370159192023An epigenetic switch controls an alternative NR2F2 isoform that unleashes a metastatic program in melanoma.4
370393672023Inflammation and DKK1-induced AKT activation contribute to endothelial dysfunction following NR2F2 loss.6
375007252023Heterozygous rare variants in NR2F2 cause a recognizable multiple congenital anomaly syndrome with developmental delays.4
343155772022Exome sequencing of fetuses with congenital diaphragmatic hernia supports a causal role for NR2F2, PTPN11, and WT1 variants.5
349108302022Abnormal hsa_circ_0003948 expression affects chronic periodontitis development by regulating miR-144-3p/NR2F2/PTEN signaling.7
356668052022The nuclear receptors SF1 and COUP-TFII cooperate on the Insl3 promoter in Leydig cells.6
343155772022Exome sequencing of fetuses with congenital diaphragmatic hernia supports a causal role for NR2F2, PTPN11, and WT1 variants.5
349108302022Abnormal hsa_circ_0003948 expression affects chronic periodontitis development by regulating miR-144-3p/NR2F2/PTEN signaling.7
356668052022The nuclear receptors SF1 and COUP-TFII cooperate on the Insl3 promoter in Leydig cells.6
321073312021The Coup-TFII orphan nuclear receptor is an activator of the γ-globin gene.5
332008002021miR-194-5p serves a suppressive role in human keloid fibroblasts via targeting NR2F2.6
336644542021YAP1 overexpression contributes to the development of enzalutamide resistance by induction of cancer stemness and lipid metabolism in prostate cancer.27

Citation

Dessen P

NR2F2 (nuclear receptor subfamily 2 group F member 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47203