ANAPC1 (anaphase promoting complex subunit 1)

2007-04-01  

Identity

HGNC
ANAPC1
LOCATION
2q13
LOCUSID
64682
ALIAS
APC1,MCPR,TSG24
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 64682
MIM: 608473
HGNC: 19988
Ensembl: ENSG00000153107

Variants:

dbSNP: 64682
ClinVar: 64682
TCGA: ENSG00000153107
COSMIC: ANAPC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000153107ENST00000341068Q9H1A4
ENSG00000153107ENST00000427997H0Y564
ENSG00000153107ENST00000451367F8WAS1
ENSG00000153107ENST00000628342F8WAS1
ENSG00000153107ENST00000643447A0A2R8YF63

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Ubiquitin mediated proteolysisKEGGko04120
Progesterone-mediated oocyte maturationKEGGko04914
Cell cycleKEGGhsa04110
Ubiquitin mediated proteolysisKEGGhsa04120
Progesterone-mediated oocyte maturationKEGGhsa04914
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
APC/C complexKEGGhsa_M00389
APC/C complexKEGGM00389
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
Mitotic Spindle CheckpointREACTOMER-HSA-69618
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint componentsREACTOMER-HSA-141405
Inactivation of APC/C via direct inhibition of the APC/C complexREACTOMER-HSA-141430
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Regulation of mitotic cell cycleREACTOMER-HSA-453276
APC/C-mediated degradation of cell cycle proteinsREACTOMER-HSA-174143
Regulation of APC/C activators between G1/S and early anaphaseREACTOMER-HSA-176408
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteinsREACTOMER-HSA-176814
Phosphorylation of the APC/CREACTOMER-HSA-176412
APC/C:Cdc20 mediated degradation of mitotic proteinsREACTOMER-HSA-176409
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpointREACTOMER-HSA-179419
Cdc20:Phospho-APC/C mediated degradation of Cyclin AREACTOMER-HSA-174184
APC-Cdc20 mediated degradation of Nek2AREACTOMER-HSA-179409
APC/C:Cdc20 mediated degradation of Cyclin BREACTOMER-HSA-174048
APC/C:Cdc20 mediated degradation of SecurinREACTOMER-HSA-174154
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphaseREACTOMER-HSA-176407
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1REACTOMER-HSA-174178
Autodegradation of Cdh1 by Cdh1:APC/CREACTOMER-HSA-174084
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Senescence-Associated Secretory Phenotype (SASP)REACTOMER-HSA-2559582

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
359568182022Antibody for Serine 65 Phosphorylated Ubiquitin Identifies PLK1-Mediated Phosphorylation of Mitotic Proteins and APC1.0
359568182022Antibody for Serine 65 Phosphorylated Ubiquitin Identifies PLK1-Mediated Phosphorylation of Mitotic Proteins and APC1.0
330822892020Dimerization regulates the human APC/C-associated ubiquitin-conjugating enzyme UBE2S.6
330822892020Dimerization regulates the human APC/C-associated ubiquitin-conjugating enzyme UBE2S.6
304826182019Posing the APC/C E3 Ubiquitin Ligase to Orchestrate Cell Division.62
308945462019Sequence variation at ANAPC1 accounts for 24% of the variability in corneal endothelial cell density.18
313032642019Mutations in ANAPC1, Encoding a Scaffold Subunit of the Anaphase-Promoting Complex, Cause Rothmund-Thomson Syndrome Type 1.22
304826182019Posing the APC/C E3 Ubiquitin Ligase to Orchestrate Cell Division.62
308945462019Sequence variation at ANAPC1 accounts for 24% of the variability in corneal endothelial cell density.18
313032642019Mutations in ANAPC1, Encoding a Scaffold Subunit of the Anaphase-Promoting Complex, Cause Rothmund-Thomson Syndrome Type 1.22
285051052017New Functions of APC/C Ubiquitin Ligase in the Nervous System and Its Role in Alzheimer's Disease.14
285051052017New Functions of APC/C Ubiquitin Ligase in the Nervous System and Its Role in Alzheimer's Disease.14
276016672016WD40 domain of Apc1 is critical for the coactivator-induced allosteric transition that stimulates APC/C catalytic activity.12
276556962016Identification of the APC/C co-factor FZR1 as a novel therapeutic target for multiple myeloma.14
279399432016The Mitotic Checkpoint Complex Requires an Evolutionary Conserved Cassette to Bind and Inhibit Active APC/C.23

Citation

Dessen P

ANAPC1 (anaphase promoting complex subunit 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47289/teaching-explorer/css/lib/js/web-card-_common.js