ANGPTL3 (angiopoietin like 3)

2007-04-01  

Identity

HGNC
LOCATION
1p31.3
LOCUSID
ALIAS
ANG-5,ANGPT5,ANL3,FHBL2

Other Information

Locus ID:

NCBI: 27329
MIM: 604774
HGNC: 491
Ensembl: ENSG00000132855

Variants:

dbSNP: 27329
ClinVar: 27329
TCGA: ENSG00000132855
COSMIC: ANGPTL3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132855ENST00000371129Q9Y5C1

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Lipoprotein metabolismREACTOMER-HSA-174824
Chylomicron-mediated lipid transportREACTOMER-HSA-174800

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
376340842024ANGPTL3 negatively regulates IL-1β-induced NF-κB activation by inhibiting the IL1R1-associated signaling complex assembly.1
382198202024ANGPTL3 deficiency impairs lipoprotein production and produces adaptive changes in hepatic lipid metabolism.3
383852902024ANGPTL3 Downregulation Increases Intracellular Lipids by Reducing Energy Utilization.1
384140082024Pre-operative levels of angiopoietin protein-like 3 (ANGPTL3) in women diagnosed with high-grade serous carcinoma of the ovary.1
384252312024Correlation between the serum FABP4, ANGPTL3, and ANGPTL4 levels and coronary artery disease.1
384626082024ANGPTL3 is a novel HDL component that regulates HDL function.0
386342152024Association of a genetic variant in angiopoietin-like 3 with serum HDL-C and risk of cardiovascular disease: A study of the MASHAD cohort over 6 years.1
376340842024ANGPTL3 negatively regulates IL-1β-induced NF-κB activation by inhibiting the IL1R1-associated signaling complex assembly.1
382198202024ANGPTL3 deficiency impairs lipoprotein production and produces adaptive changes in hepatic lipid metabolism.3
383852902024ANGPTL3 Downregulation Increases Intracellular Lipids by Reducing Energy Utilization.1
384140082024Pre-operative levels of angiopoietin protein-like 3 (ANGPTL3) in women diagnosed with high-grade serous carcinoma of the ovary.1
384252312024Correlation between the serum FABP4, ANGPTL3, and ANGPTL4 levels and coronary artery disease.1
384626082024ANGPTL3 is a novel HDL component that regulates HDL function.0
386342152024Association of a genetic variant in angiopoietin-like 3 with serum HDL-C and risk of cardiovascular disease: A study of the MASHAD cohort over 6 years.1
359769552023Increased Levels of ANGPTL3 and CTRP9 in Patients With Obstructive Sleep Apnea and Their Relation to Insulin Resistance and Lipid Metabolism and Markers of Endothelial Dysfunction.1

Citation

Dessen P

ANGPTL3 (angiopoietin like 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47315/angptl3