MED14 (mediator complex subunit 14)

2007-04-01 Affiliation

Identity

HGNC

MED14

LOCATION

Xp11.4

LOCUSID

9282

ALIAS

CRSP150,CRSP2,CSRP,CXorf4,DRIP150,EXLM1,RGR1,TRAP170

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9282
MIM: 300182
HGNC: 2370
Ensembl: ENSG00000180182

Variants:

dbSNP: 9282
ClinVar: 9282
TCGA: ENSG00000180182
COSMIC: MED14

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000180182	ENST00000324817	O60244
ENSG00000180182	ENST00000416199	H7C017
ENSG00000180182	ENST00000433003	H7C3E5

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Thyroid hormone signaling pathway	KEGG	hsa04919
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolism	REACTOME	R-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	REACTOME	R-HSA-400206
PPARA activates gene expression	REACTOME	R-HSA-1989781
Developmental Biology	REACTOME	R-HSA-1266738
Transcriptional regulation of white adipocyte differentiation	REACTOME	R-HSA-381340

References

Pubmed ID	Year	Title	Citations
28813667	2017	Human GW182 Paralogs Are the Central Organizers for RNA-Mediated Control of Transcription.	27
28813667	2017	Human GW182 Paralogs Are the Central Organizers for RNA-Mediated Control of Transcription.	27
25383669	2014	Reconstitution of active human core Mediator complex reveals a critical role of the MED14 subunit.	71
25383669	2014	Reconstitution of active human core Mediator complex reveals a critical role of the MED14 subunit.	71
23572530	2013	Vitamin D enhances glucocorticoid action in human monocytes: involvement of granulocyte-macrophage colony-stimulating factor and mediator complex subunit 14.	34
23572530	2013	Vitamin D enhances glucocorticoid action in human monocytes: involvement of granulocyte-macrophage colony-stimulating factor and mediator complex subunit 14.	34
17306756	2007	Coactivation of estrogen receptor alpha (ER alpha)/Sp1 by vitamin D receptor interacting protein 150 (DRIP150).	5
17306756	2007	Coactivation of estrogen receptor alpha (ER alpha)/Sp1 by vitamin D receptor interacting protein 150 (DRIP150).	5
16239257	2006	MED14 and MED1 differentially regulate target-specific gene activation by the glucocorticoid receptor.	79
16239257	2006	MED14 and MED1 differentially regulate target-specific gene activation by the glucocorticoid receptor.	79
15625066	2005	DRIP150 coactivation of estrogen receptor alpha in ZR-75 breast cancer cells is independent of LXXLL motifs.	12
15625066	2005	DRIP150 coactivation of estrogen receptor alpha in ZR-75 breast cancer cells is independent of LXXLL motifs.	12
12509459	2003	Role of metazoan mediator proteins in interferon-responsive transcription.	35
12825353	2003	Refinement of the physical location and the genomic characterization of the CRSP2 (EXLM1) gene on Xp11.4.	0
12509459	2003	Role of metazoan mediator proteins in interferon-responsive transcription.	35

Citation

Dessen P

MED14 (mediator complex subunit 14)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47338