IPO11 (importin 11)

2007-04-01  

Identity

HGNC
IPO11
LOCATION
5q12.1
LOCUSID
51194
ALIAS
RanBP11
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51194
MIM: 610889
HGNC: 20628
Ensembl: ENSG00000086200

Variants:

dbSNP: 51194
ClinVar: 51194
TCGA: ENSG00000086200
COSMIC: IPO11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000086200ENST00000325324Q9UI26
ENSG00000086200ENST00000409296Q9UI26
ENSG00000086200ENST00000409534E7EMB7
ENSG00000086200ENST00000413749F8WBN4
ENSG00000086200ENST00000424533F8WDV0
ENSG00000086200ENST00000505902D6RCQ2
ENSG00000086200ENST00000506200D6RJB1
ENSG00000086200ENST00000511713H0Y8M5
ENSG00000086200ENST00000514647D6RCN7

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
335715912021The nuclear transporter importin-11 regulates the Wnt/β-catenin pathway and acts as a tumor promoter in glioma.3
346495672021Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling.48
335715912021The nuclear transporter importin-11 regulates the Wnt/β-catenin pathway and acts as a tumor promoter in glioma.3
346495672021Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling.48
318810792020IPO11 mediates βcatenin nuclear import in a subset of colorectal cancers.16
318810792020IPO11 mediates βcatenin nuclear import in a subset of colorectal cancers.16
296026372018Importin-11 overexpression promotes the migration, invasion, and progression of bladder cancer associated with the deregulation of CDKN1A and THBS1.12
296026372018Importin-11 overexpression promotes the migration, invasion, and progression of bladder cancer associated with the deregulation of CDKN1A and THBS1.12
282581032017Protecting PTEN in the Nucleus.0
282581032017Protecting PTEN in the Nucleus.0
276893322016Whole-exome sequencing of muscle-invasive bladder cancer identifies recurrent copy number variation in IPO11 and prognostic significance of importin-11 overexpression on poor survival.4
276893322016Whole-exome sequencing of muscle-invasive bladder cancer identifies recurrent copy number variation in IPO11 and prognostic significance of importin-11 overexpression on poor survival.4
253785862015The ubiquitin-conjugating enzyme UBE2E3 and its import receptor importin-11 regulate the localization and activity of the antioxidant transcription factor NRF2.19
260791292015Significant association between rare IPO11-HTR1A variants and attention deficit hyperactivity disorder in Caucasians.4
253785862015The ubiquitin-conjugating enzyme UBE2E3 and its import receptor importin-11 regulate the localization and activity of the antioxidant transcription factor NRF2.19

Citation

Dessen P

IPO11 (importin 11)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47389/favicon/tumors-explorer/