KDM4B (lysine demethylase 4B)

2007-04-01  

Identity

HGNC
KDM4B
LOCATION
19p13.3
LOCUSID
23030
ALIAS
JMJD2B,MRD65,TDRD14B
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23030
MIM: 609765
HGNC: 29136
Ensembl: ENSG00000127663

Variants:

dbSNP: 23030
ClinVar: 23030
TCGA: ENSG00000127663
COSMIC: KDM4B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127663ENST00000159111A0A0C4DFL8
ENSG00000127663ENST00000381759O94953
ENSG00000127663ENST00000536461F5GX28
ENSG00000127663ENST00000588337K7ES23
ENSG00000127663ENST00000588361K7EQ54
ENSG00000127663ENST00000611640F5GX28

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
DNA RepairREACTOMER-HSA-73894
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HDMs demethylate histonesREACTOMER-HSA-3214842
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
DNA Double Strand Break ResponseREACTOMER-HSA-5693606
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksREACTOMER-HSA-5693565

References

Pubmed IDYearTitleCitations
372498132024KDM4B down-regulation facilitated breast cancer cell stemness via PHGDH upregulation in H3K36me3-dependent manner.2
386608402024[The Regulatory Effect of RNA m(6) A Methylation Modification on KDM4B Gene Expression in t (8;21) AML Cells by MeRIP-qPCR].0
372498132024KDM4B down-regulation facilitated breast cancer cell stemness via PHGDH upregulation in H3K36me3-dependent manner.2
386608402024[The Regulatory Effect of RNA m(6) A Methylation Modification on KDM4B Gene Expression in t (8;21) AML Cells by MeRIP-qPCR].0
369524762023Histone demethylase KDM4B contributes to advanced clear cell renal carcinoma and association with copy number variations and cell cycle progression.2
370875292023HIF1α-mediated transactivation of WTAP promotes AML cell proliferation via m(6)A-dependent stabilization of KDM4B mRNA.3
380933122023Histone demethylase KDM4B accelerates the progression of glioblastoma via the epigenetic regulation of MYC stability.0
369524762023Histone demethylase KDM4B contributes to advanced clear cell renal carcinoma and association with copy number variations and cell cycle progression.2
370875292023HIF1α-mediated transactivation of WTAP promotes AML cell proliferation via m(6)A-dependent stabilization of KDM4B mRNA.3
380933122023Histone demethylase KDM4B accelerates the progression of glioblastoma via the epigenetic regulation of MYC stability.0
354852902022KDM4B, a potential prognostic biomarker revealed by large-scale public databases and clinical samples in uterine corpus endometrial carcinoma.4
355259102022Loss of KDM4B impairs osteogenic differentiation of OMSCs and promotes oral bone aging.6
362173822022Histone H3K9 demethylase JMJD2B/KDM4B promotes osteogenic differentiation of bone marrow-derived mesenchymal stem cells by regulating H3K9me2 on RUNX2.3
354852902022KDM4B, a potential prognostic biomarker revealed by large-scale public databases and clinical samples in uterine corpus endometrial carcinoma.4
355259102022Loss of KDM4B impairs osteogenic differentiation of OMSCs and promotes oral bone aging.6

Citation

Dessen P

KDM4B (lysine demethylase 4B)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47437