COX15 (cytochrome c oxidase assembly homolog COX15)

2007-04-01  

Identity

HGNC
COX15
LOCATION
10q24.2
LOCUSID
1355
ALIAS
CEMCOX2,MC4DN6
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1355
MIM: 603646
HGNC: 2263
Ensembl: ENSG00000014919

Variants:

dbSNP: 1355
ClinVar: 1355
TCGA: ENSG00000014919
COSMIC: COX15

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000014919ENST00000016171Q7KZN9
ENSG00000014919ENST00000370483Q7KZN9

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Oxidative phosphorylationKEGGko00190
Porphyrin and chlorophyll metabolismKEGGko00860
Oxidative phosphorylationKEGGhsa00190
Porphyrin and chlorophyll metabolismKEGGhsa00860
Metabolic pathwaysKEGGhsa01100
Cytochrome c oxidaseKEGGhsa_M00154
Cytochrome c oxidaseKEGGM00154
MetabolismREACTOMER-HSA-1430728
Metabolism of porphyrinsREACTOMER-HSA-189445
Heme biosynthesisREACTOMER-HSA-189451

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
345476262021Cox15 is a novel oncogene that required for lung cancer cell proliferation.4
345476262021Cox15 is a novel oncogene that required for lung cancer cell proliferation.4
322329622020Phenotypic variability and mutation hotspot in COX15-related Leigh syndrome.3
322329622020Phenotypic variability and mutation hotspot in COX15-related Leigh syndrome.3
269408732016Analysis of Oligomerization Properties of Heme a Synthase Provides Insights into Its Function in Eukaryotes.16
269408732016Analysis of Oligomerization Properties of Heme a Synthase Provides Insights into Its Function in Eukaryotes.16
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
198269012009Analysis of the genes coding for subunit 10 and 15 of cytochrome c oxidase in Alzheimer's disease.11
198269012009Analysis of the genes coding for subunit 10 and 15 of cytochrome c oxidase in Alzheimer's disease.11
200497012009Expression of the alternative oxidase complements cytochrome c oxidase deficiency in human cells.36
198269012009Analysis of the genes coding for subunit 10 and 15 of cytochrome c oxidase in Alzheimer's disease.11
198269012009Analysis of the genes coding for subunit 10 and 15 of cytochrome c oxidase in Alzheimer's disease.11
200497012009Expression of the alternative oxidase complements cytochrome c oxidase deficiency in human cells.36
179450212007Enhancement of cell proliferation in various mammalian cell lines by gene insertion of a cyclin-dependent kinase homolog.13

Citation

Dessen P

COX15 (cytochrome c oxidase assembly homolog COX15)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47442