PI4K2B (phosphatidylinositol 4-kinase type 2 beta)

2007-04-01 Affiliation

Identity

HGNC

PI4K2B

LOCATION

4p15.2

LOCUSID

55300

ALIAS

PI4KIIB,PIK42B

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 55300
MIM: 612101
HGNC: 18215
Ensembl: ENSG00000038210

Variants:

dbSNP: 55300
ClinVar: 55300
TCGA: ENSG00000038210
COSMIC: PI4K2B

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000038210	ENST00000264864	Q8TCG2
ENSG00000038210	ENST00000512921	G5E9Z4

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Inositol phosphate metabolism	KEGG	ko00562
Phosphatidylinositol signaling system	KEGG	ko04070
Inositol phosphate metabolism	KEGG	hsa00562
Phosphatidylinositol signaling system	KEGG	hsa04070
Metabolic pathways	KEGG	hsa01100
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4	KEGG	hsa_M00130
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4	KEGG	M00130
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Phospholipid metabolism	REACTOME	R-HSA-1483257
PI Metabolism	REACTOME	R-HSA-1483255
Synthesis of PIPs at the ER membrane	REACTOME	R-HSA-1483248
Synthesis of PIPs at the Golgi membrane	REACTOME	R-HSA-1660514
Synthesis of PIPs at the plasma membrane	REACTOME	R-HSA-1660499
Synthesis of PIPs at the early endosome membrane	REACTOME	R-HSA-1660516

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
27068535	2016	Type II PI4-kinases control Weibel-Palade body biogenesis and von Willebrand factor structure in human endothelial cells.	9
27068535	2016	Type II PI4-kinases control Weibel-Palade body biogenesis and von Willebrand factor structure in human endothelial cells.	9
26143926	2015	The high-resolution crystal structure of phosphatidylinositol 4-kinase IIβ and the crystal structure of phosphatidylinositol 4-kinase IIα containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design.	9
26143926	2015	The high-resolution crystal structure of phosphatidylinositol 4-kinase IIβ and the crystal structure of phosphatidylinositol 4-kinase IIα containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design.	9
24481753	2014	Type II phosphatidylinositol 4-kinases interact with FcεRIγ subunit in RBL-2H3 cells.	0
24972704	2014	Type II PtdIns 4-kinase β associates with CD4-p56lck complex and is involved in CD4 receptor signaling.	0
24481753	2014	Type II phosphatidylinositol 4-kinases interact with FcεRIγ subunit in RBL-2H3 cells.	0
24972704	2014	Type II PtdIns 4-kinase β associates with CD4-p56lck complex and is involved in CD4 receptor signaling.	0
23619705	2013	Type II phosphatidylinositol 4-kinase β is an integral signaling component of early T cell activation mechanisms.	3
23619705	2013	Type II phosphatidylinositol 4-kinase β is an integral signaling component of early T cell activation mechanisms.	3
20583997	2010	PIP4Kbeta interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kalpha.	40
20583997	2010	PIP4Kbeta interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kalpha.	40
19539307	2009	A case-control association study and family-based expression analysis of the bipolar disorder candidate gene PI4K2B.	4
19539307	2009	A case-control association study and family-based expression analysis of the bipolar disorder candidate gene PI4K2B.	4
19539307	2009	A case-control association study and family-based expression analysis of the bipolar disorder candidate gene PI4K2B.	4

Citation

Dessen P

PI4K2B (phosphatidylinositol 4-kinase type 2 beta)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47450