RGS17 (regulator of G-protein signaling 17)

2011-10-01 Chenguang Li , Lei Wang , Yihua Sun , Haiquan Chen Affiliation

Department of Thoracic Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China

Identity

HGNC

RGS17

LOCATION

6q25.2

LOCUSID

26575

ALIAS

RGS-17,RGSZ2,hRGS17

FUSION GENES

Show Gene Fusions

DNA/RNA

Description

The RGS17 gene spans over a region of 120 kbp DNA including 4 coding exons and 1 non-coding exon (exon 1).

Transcription

The RGS17 gene mRNA consists of about 1472 nucleotides with an open reading frame (ORF) of 633 bases.

Pseudogene

RGS17P1 regulator of G-protein signaling 17 pseudogene 1.

Proteins

Note

210 amino acids; 24 kDa.

Diagram of the RGS17 protein in scale. The numbers represent specific residues. The regions are RGS_RZ-like (Regulator of G protein signaling (RGS) domain found in the RZ protein), putative G-alpha interaction site. C: Carboxyl-terminal; N: Amino-terminal.

Description

The RGS17 protein consists of 210 amino acid residues. This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region.

Expression

Widely expressed in human organs.

Localisation

Its cellular localization has not been formally monitored to date.

Function

The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. RGS proteins are GTPase-activating proteins for Gi and Gq class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.

Homology

The RGS17 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, and zebrafish.

Mutations

Germinal

No germline mutations in this gene have been reported.

Somatic

A synonymous-coding somatic mutations of this gene is reported in pancreas cancer at codon 166, P166P (COSMIC).

Implicated in

Entity name

Various cancer

Note

Lung cancer, prostate cancer.

Disease

RSG17 is overexpressed in lung and prostate cancer (James et al., 2009). Expression of RGS17 is up-regulated in 80% of lung tumors, and also up-regulated in prostate tumors. Overexpression of RGS17 induce and maintain cell proliferation.

Entity name

Lung cancer

Disease

hsa-mir-182 is involved in the down regulation of RGS17 expression through two conserved sites located in its 3 UTR region (Sun et al., 2010).
Two SNPs in the first intron of RGS17 (rs4083914 and rs9479510) were found associated with familial lung cancer susceptibility (You et al., 2009).

Entity name

Ovarian cancer

Disease

RGS2, RGS5, RGS10 and RGS17 transcripts are expressed at significantly lower levels in cells resistant to chemotherapy compared with parental, chemo-sensitive cells in ovarian cancer cells (Hooks et al., 2010).

Prognosis

RGS17 loss of expression contributes to the development of chemoresistance in ovarian cancer cells.

Article Bibliography

Pubmed ID	Last Year	Title	Authors
21044322	2010	Regulators of G-Protein signaling RGS10 and RGS17 regulate chemoresistance in ovarian cancer cells.	Hooks SB et al
19244110	2009	RGS17, an overexpressed gene in human lung and prostate cancer, induces tumor cell proliferation through the cyclic AMP-PKA-CREB pathway.	James MA et al
20420807	2010	Hsa-mir-182 suppresses lung tumorigenesis through down regulation of RGS17 expression in vitro.	Sun Y et al
19351763	2009	Fine mapping of chromosome 6q23-25 region in familial lung cancer families reveals RGS17 as a likely candidate gene.	You M et al

Other Information

Locus ID:

NCBI: 26575
MIM: 607191
HGNC: 14088
Ensembl: ENSG00000091844

Variants:

dbSNP: 26575
ClinVar: 26575
TCGA: ENSG00000091844
COSMIC: RGS17

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000091844	ENST00000206262	Q9UGC6
ENSG00000091844	ENST00000367225	Q9UGC6

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (z) signalling events	REACTOME	R-HSA-418597

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA447321	Depressive Disorder, Major	Disease	ClinicalAnnotation	associated		PD
PA452229	antidepressants	Chemical	ClinicalAnnotation	associated		PD

References

Pubmed ID	Year	Title	Citations
37094862	2023	Hsa_circ_0000285-Mediated miR-599/RGS17 Axis Participates in the Pathogenesis of Abdominal Aortic Aneurysm by Regulating the Functions of Vascular Smooth Muscle Cells.	0
37094862	2023	Hsa_circ_0000285-Mediated miR-599/RGS17 Axis Participates in the Pathogenesis of Abdominal Aortic Aneurysm by Regulating the Functions of Vascular Smooth Muscle Cells.	0
34002599	2021	MiR-203 inhibits cell proliferation, invasion, and migration of ovarian cancer through regulating RGS17.	4
34002599	2021	MiR-203 inhibits cell proliferation, invasion, and migration of ovarian cancer through regulating RGS17.	4
30940727	2019	High-resolution structure of RGS17 suggests a role for Ca(2+) in promoting the GTPase-activating protein activity by RZ subfamily members.	2
31081094	2019	MiRNA-199 inhibits malignant progression of lung cancer through mediating RGS17.	11
31454494	2019	Long non-coding RNA Linc00483 accelerated tumorigenesis of cervical cancer by regulating miR-508-3p/RGS17 axis.	14
30940727	2019	High-resolution structure of RGS17 suggests a role for Ca(2+) in promoting the GTPase-activating protein activity by RZ subfamily members.	2
31081094	2019	MiRNA-199 inhibits malignant progression of lung cancer through mediating RGS17.	11
31454494	2019	Long non-coding RNA Linc00483 accelerated tumorigenesis of cervical cancer by regulating miR-508-3p/RGS17 axis.	14
28337960	2018	G-Protein Signaling Protein-17 (RGS17) Is Upregulated and Promotes Tumor Growth and Migration in Human Colorectal Carcinoma.	4
29351497	2018	Screen Targeting Lung and Prostate Cancer Oncogene Identifies Novel Inhibitors of RGS17 and Problematic Chemical Substructures.	2
29559347	2018	MicroRNA-199 suppresses cell proliferation, migration and invasion by downregulating RGS17 in hepatocellular carcinoma.	21
28337960	2018	G-Protein Signaling Protein-17 (RGS17) Is Upregulated and Promotes Tumor Growth and Migration in Human Colorectal Carcinoma.	4
29351497	2018	Screen Targeting Lung and Prostate Cancer Oncogene Identifies Novel Inhibitors of RGS17 and Problematic Chemical Substructures.	2

Citation

Chenguang Li ; Lei Wang ; Yihua Sun ; Haiquan Chen

RGS17 (regulator of G-protein signaling 17)

Atlas Genet Cytogenet Oncol Haematol. 2011-10-01

Online version: http://atlasgeneticsoncology.org/gene/47522