RNF144A (ring finger protein 144A)

2007-04-01  

Identity

HGNC
RNF144A
LOCATION
2p25.1
LOCUSID
9781
ALIAS
RNF144,UBCE7IP4,hUIP4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9781
HGNC: 20457
Ensembl: ENSG00000151692

Variants:

dbSNP: 9781
ClinVar: 9781
TCGA: ENSG00000151692
COSMIC: RNF144A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000151692ENST00000320892P50876
ENSG00000151692ENST00000416587C9JLH4
ENSG00000151692ENST00000432850H7C3G0
ENSG00000151692ENST00000433456C9JLH4

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Protein ubiquitinationREACTOMER-HSA-8852135
E3 ubiquitin ligases ubiquitinate target proteinsREACTOMER-HSA-8866654

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA166128121cardiotoxicityDiseaseMultilinkAnnotationassociated26340055

References

Pubmed IDYearTitleCitations
351038562022RNF144A exerts tumor suppressor function in breast cancer through targeting YY1 for proteasomal degradation to downregulate GMFG expression.5
351038562022RNF144A exerts tumor suppressor function in breast cancer through targeting YY1 for proteasomal degradation to downregulate GMFG expression.5
314063032020RNF144A functions as a tumor suppressor in breast cancer through ubiquitin ligase activity-dependent regulation of stability and oncogenic functions of HSPA2.31
325579732020Solution structure of the zinc finger domain of human RNF144A ubiquitin ligase.1
330672542020RNF144a induces ERK-dependent cell death under oxidative stress via downregulation of vaccinia-related kinase 3.3
314063032020RNF144A functions as a tumor suppressor in breast cancer through ubiquitin ligase activity-dependent regulation of stability and oncogenic functions of HSPA2.31
325579732020Solution structure of the zinc finger domain of human RNF144A ubiquitin ligase.1
330672542020RNF144a induces ERK-dependent cell death under oxidative stress via downregulation of vaccinia-related kinase 3.3
294733202018Epigenetic silencing of RNF144A expression in breast cancer cells through promoter hypermethylation and MBD4.11
301710752018RNF144A sustains EGFR signaling to promote EGF-dependent cell proliferation.10
294733202018Epigenetic silencing of RNF144A expression in breast cancer cells through promoter hypermethylation and MBD4.11
301710752018RNF144A sustains EGFR signaling to promote EGF-dependent cell proliferation.10
262168822015Regulation of RNF144A E3 Ubiquitin Ligase Activity by Self-association through Its Transmembrane Domain.15
262168822015Regulation of RNF144A E3 Ubiquitin Ligase Activity by Self-association through Its Transmembrane Domain.15
249797662014RNF144A, an E3 ubiquitin ligase for DNA-PKcs, promotes apoptosis during DNA damage.44

Citation

Dessen P

RNF144A (ring finger protein 144A)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47523