IYD (iodotyrosine deiodinase)

2007-05-01  

Identity

HGNC
LOCATION
6q25.1
LOCUSID
ALIAS
C6orf71,DEHAL1,IYD-1,TDH4
FUSION GENES

Other Information

Locus ID:

NCBI: 389434
MIM: 612025
HGNC: 21071
Ensembl: ENSG00000009765

Variants:

dbSNP: 389434
ClinVar: 389434
TCGA: ENSG00000009765
COSMIC: IYD

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000009765ENST00000229447Q6PHW0
ENSG00000009765ENST00000344419Q6PHW0
ENSG00000009765ENST00000367335Q6PHW0
ENSG00000009765ENST00000392255C9JXJ9
ENSG00000009765ENST00000392256Q6PHW0
ENSG00000009765ENST00000422583H7C0X6
ENSG00000009765ENST00000425615F5H543
ENSG00000009765ENST00000500320F6VN83

Expression (GTEx)

0
50
100
150
200
250
300
350
400

Pathways

PathwaySourceExternal ID
Thyroid hormone synthesisKEGGhsa04918
Thyroid hormone synthesisKEGGko04918
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Amine-derived hormonesREACTOMER-HSA-209776
Thyroxine biosynthesisREACTOMER-HSA-209968

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
366339212023Congenital Hypothyroidism in Two Sudanese Families Harboring a Novel Iodotyrosine Deiodinase Mutation (IYD R279C).0
366339212023Congenital Hypothyroidism in Two Sudanese Families Harboring a Novel Iodotyrosine Deiodinase Mutation (IYD R279C).0
300522942019Redox control of iodotyrosine deiodinase.8
300522942019Redox control of iodotyrosine deiodinase.8
253956212015A switch between one- and two-electron chemistry of the human flavoprotein iodotyrosine deiodinase is controlled by substrate.24
261514302015Rapid kinetics of dehalogenation promoted by iodotyrosine deiodinase from human thyroid.16
253956212015A switch between one- and two-electron chemistry of the human flavoprotein iodotyrosine deiodinase is controlled by substrate.24
261514302015Rapid kinetics of dehalogenation promoted by iodotyrosine deiodinase from human thyroid.16
225359722012Iodotyrosine deiodinase defect identified via genome-wide approach.7
225359722012Iodotyrosine deiodinase defect identified via genome-wide approach.7
218706042011[Biochemical characteristics of iodperoxidase activity of human saliva].0
218706042011[Biochemical characteristics of iodperoxidase activity of human saliva].0
202987472010Genetics and phenomics of hypothyroidism and goiter due to iodotyrosine deiodinase (DEHAL1) gene mutations.20
202987472010Genetics and phenomics of hypothyroidism and goiter due to iodotyrosine deiodinase (DEHAL1) gene mutations.20
184346512008Mutations in the iodotyrosine deiodinase gene and hypothyroidism.48

Citation

Dessen P

IYD (iodotyrosine deiodinase)

Atlas Genet Cytogenet Oncol Haematol. 2007-05-01

Online version: http://atlasgeneticsoncology.org/gene/47543/iyd