FXR1 (FMR1 autosomal homolog 1)

2007-06-01  

Identity

HGNC
LOCATION
3q26.33
LOCUSID
ALIAS
FXR1P,MYOPMIL,MYORIBF
FUSION GENES

Other Information

Locus ID:

NCBI: 8087
MIM: 600819
HGNC: 4023
Ensembl: ENSG00000114416

Variants:

dbSNP: 8087
ClinVar: 8087
TCGA: ENSG00000114416
COSMIC: FXR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000114416ENST00000305586P51114
ENSG00000114416ENST00000357559P51114
ENSG00000114416ENST00000445140P51114
ENSG00000114416ENST00000465551C9IZ22
ENSG00000114416ENST00000468861E7EU85
ENSG00000114416ENST00000469882C9JZE0
ENSG00000114416ENST00000480918B4DXZ6
ENSG00000114416ENST00000482125H7C4S4
ENSG00000114416ENST00000484042C9JAJ4
ENSG00000114416ENST00000484790C9J5B4
ENSG00000114416ENST00000484958C9JY20
ENSG00000114416ENST00000491062E9PFF5
ENSG00000114416ENST00000491674C9JYQ6

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
RNA transportKEGGko03013
RNA transportKEGGhsa03013
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Oncogenic MAPK signalingREACTOMER-HSA-6802957
Signaling by BRAF and RAF fusionsREACTOMER-HSA-6802952

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
382382862024The multifaceted role of Fragile X-Related Protein 1 (FXR1) in cellular processes: an updated review on cancer and clinical applications.0
385874862024LLPS of FXR proteins drives replication organelle clustering for β-coronaviral proliferation.2
382382862024The multifaceted role of Fragile X-Related Protein 1 (FXR1) in cellular processes: an updated review on cancer and clinical applications.0
385874862024LLPS of FXR proteins drives replication organelle clustering for β-coronaviral proliferation.2
365030482023CircSETD3 mediates acquired resistance to gefitinib in non-small lung cancer cells by FXR1/ECT2 pathway.2
367306182023FXR1 facilitates axitinib resistance in clear cell renal cell carcinoma via regulating KEAP1/Nrf2 signaling pathway.3
367323562023FMRP, FXR1 protein and Dlg4 mRNA, which are associated with fragile X syndrome, are involved in the ubiquitin-proteasome system.2
367490742023Fragile X-Related Protein FXR1 Controls Human Adenovirus Capsid mRNA Metabolism.2
370433512023FXR1 regulates vascular smooth muscle cell cytoskeleton, VSMC contractility, and blood pressure by multiple mechanisms.1
365030482023CircSETD3 mediates acquired resistance to gefitinib in non-small lung cancer cells by FXR1/ECT2 pathway.2
367306182023FXR1 facilitates axitinib resistance in clear cell renal cell carcinoma via regulating KEAP1/Nrf2 signaling pathway.3
367323562023FMRP, FXR1 protein and Dlg4 mRNA, which are associated with fragile X syndrome, are involved in the ubiquitin-proteasome system.2
367490742023Fragile X-Related Protein FXR1 Controls Human Adenovirus Capsid mRNA Metabolism.2
370433512023FXR1 regulates vascular smooth muscle cell cytoskeleton, VSMC contractility, and blood pressure by multiple mechanisms.1
342914162022Fragile X-Related Protein 1 (FXR1) Promotes Trophoblast Migration at Early Pregnancy via Downregulation of GDF-15 Expression.4

Citation

Dessen P

FXR1 (FMR1 autosomal homolog 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-06-01

Online version: http://atlasgeneticsoncology.org/gene/47559/fxr1