NFATC3 (nuclear factor of activated T cells 3)

2007-07-01  

Identity

HGNC
NFATC3
LOCATION
16q22.1
LOCUSID
4775
ALIAS
NF-AT4c,NFAT4,NFATX
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4775
MIM: 602698
HGNC: 7777
Ensembl: ENSG00000072736

Variants:

dbSNP: 4775
ClinVar: 4775
TCGA: ENSG00000072736
COSMIC: NFATC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000072736ENST00000329524Q12968
ENSG00000072736ENST00000329524B5B2S0
ENSG00000072736ENST00000346183Q12968
ENSG00000072736ENST00000346183B5B2S1
ENSG00000072736ENST00000349223Q12968
ENSG00000072736ENST00000539828F8VPH9
ENSG00000072736ENST00000561714F8VPH9
ENSG00000072736ENST00000562171H3BRM3
ENSG00000072736ENST00000562926H3BR83
ENSG00000072736ENST00000565750H3BU30
ENSG00000072736ENST00000568466F8VPH9
ENSG00000072736ENST00000570212H3BRS1
ENSG00000072736ENST00000575270I3L3K7

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Wnt signaling pathwayKEGGko04310
Axon guidanceKEGGko04360
T cell receptor signaling pathwayKEGGko04660
B cell receptor signaling pathwayKEGGko04662
MAPK signaling pathwayKEGGhsa04010
Wnt signaling pathwayKEGGhsa04310
Axon guidanceKEGGhsa04360
T cell receptor signaling pathwayKEGGhsa04660
B cell receptor signaling pathwayKEGGhsa04662
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Hepatitis BKEGGhsa05161
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fc epsilon receptor (FCERI) signalingREACTOMER-HSA-2454202
FCERI mediated Ca+2 mobilizationREACTOMER-HSA-2871809
C-type lectin receptors (CLRs)REACTOMER-HSA-5621481
CLEC7A (Dectin-1) signalingREACTOMER-HSA-5607764
CLEC7A (Dectin-1) induces NFAT activationREACTOMER-HSA-5607763
Th1 and Th2 cell differentiationKEGGko04658
Th1 and Th2 cell differentiationKEGGhsa04658
Th17 cell differentiationKEGGko04659
Th17 cell differentiationKEGGhsa04659

References

Pubmed IDYearTitleCitations
388628322024HNRNPA2B1 stabilizes NFATC3 levels to potentiate its combined actions with FOSL1 to mediate vasculogenic mimicry in GBM cells.0
388628322024HNRNPA2B1 stabilizes NFATC3 levels to potentiate its combined actions with FOSL1 to mediate vasculogenic mimicry in GBM cells.0
373404232023CircNFATC3 promotes the proliferation of gastric cancer through binding to IGF2BP3 and restricting its ubiquitination to enhance CCND1 mRNA stability.7
373404232023CircNFATC3 promotes the proliferation of gastric cancer through binding to IGF2BP3 and restricting its ubiquitination to enhance CCND1 mRNA stability.7
354841322022Hypoxia-induced NFATc3 deSUMOylation enhances pancreatic carcinoma progression.2
357081502022lncRNA NEAT1 promotes hypoxia-induced inflammation and fibrosis of alveolar epithelial cells via targeting miR-29a/NFATc3 axis.1
354841322022Hypoxia-induced NFATc3 deSUMOylation enhances pancreatic carcinoma progression.2
357081502022lncRNA NEAT1 promotes hypoxia-induced inflammation and fibrosis of alveolar epithelial cells via targeting miR-29a/NFATc3 axis.1
326676922021circNFATC3 sponges miR-548I acts as a ceRNA to protect NFATC3 itself and suppressed hepatocellular carcinoma progression.17
335204072021NFATc3 inhibits hepatocarcinogenesis and HBV replication via positively regulating RIG-I-mediated interferon transcription.9
338406482021Fusobacterium nucleatum Promotes Cisplatin-Resistance and Migration of Oral Squamous Carcinoma Cells by Up-Regulating Wnt5a-Mediated NFATc3 Expression.6
345702112021Macrophage NFATc3 prevents foam cell formation and atherosclerosis: evidence and mechanisms.25
326676922021circNFATC3 sponges miR-548I acts as a ceRNA to protect NFATC3 itself and suppressed hepatocellular carcinoma progression.17
335204072021NFATc3 inhibits hepatocarcinogenesis and HBV replication via positively regulating RIG-I-mediated interferon transcription.9
338406482021Fusobacterium nucleatum Promotes Cisplatin-Resistance and Migration of Oral Squamous Carcinoma Cells by Up-Regulating Wnt5a-Mediated NFATc3 Expression.6

Citation

Dessen P

NFATC3 (nuclear factor of activated T cells 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-07-01

Online version: http://atlasgeneticsoncology.org/gene/47574