APLN (apelin)

2007-07-01  

Identity

HGNC
APLN
LOCATION
Xq26.1
LOCUSID
8862
ALIAS
APEL,XNPEP2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8862
MIM: 300297
HGNC: 16665
Ensembl: ENSG00000171388

Variants:

dbSNP: 8862
ClinVar: 8862
TCGA: ENSG00000171388
COSMIC: APLN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171388ENST00000429967Q9ULZ1

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
Apelin signaling pathwayKEGGhsa04371

References

Pubmed IDYearTitleCitations
380876722024Apelin and the gut microbiome: Potential interaction in human MASLD.1
385084772024The regulatory role of the apelin/APJ axis in scarring: Identification of upstream and downstream mechanisms.0
389463822024Lack of association between serum apelin levels and sarcopenia in elderly malnourished subjects.0
380876722024Apelin and the gut microbiome: Potential interaction in human MASLD.1
385084772024The regulatory role of the apelin/APJ axis in scarring: Identification of upstream and downstream mechanisms.0
389463822024Lack of association between serum apelin levels and sarcopenia in elderly malnourished subjects.0
364424622023Plasma Level of Apelin as a Promising Factor for Retinopathy of Prematurity.2
366324532023Apelin promotes osteosarcoma metastasis by upregulating PLOD2 expression via the Hippo signaling pathway and hsa_circ_0000004/miR-1303 axis.7
366332012023Efficacy of serum apelin and galectin-3 as potential predictors of mortality in severe COVID-19 patients.4
367857902023The Interaction of Apelin and FGFR1 Ameliorated the Kidney Fibrosis through Suppression of TGFβ-Induced Endothelial-to-Mesenchymal Transition.1
370519082023Rbpj Deficiency Disrupts Vascular Remodeling via Abnormal Apelin and Cdc42 (Cell Division Cycle 42) Activity in Brain Arteriovenous Malformation.2
370625022023Apelin/ELABELA-APJ system in cardiac hypertrophy: Regulatory mechanisms and therapeutic potential.0
371759012023Apelin as a Potential Regulator of Peak Athletic Performance.3
372462382023Apelin and Visfatin Expression in Placental Tissue in Women With Preeclampsia and Overweight/Obesity.1
373527752023Apelin is found in human sperm and testis and is raised in inflammatory pathological conditions.3

Citation

Dessen P

APLN (apelin)

Atlas Genet Cytogenet Oncol Haematol. 2007-07-01

Online version: http://atlasgeneticsoncology.org/gene/47581