NODAL (nodal growth differentiation factor)

2007-07-01  

Identity

HGNC
NODAL
LOCATION
10q22.1
LOCUSID
4838
ALIAS
HTX5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4838
MIM: 601265
HGNC: 7865
Ensembl: ENSG00000156574

Variants:

dbSNP: 4838
ClinVar: 4838
TCGA: ENSG00000156574
COSMIC: NODAL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156574ENST00000287139Q96S42
ENSG00000156574ENST00000414871H7C0E4

Expression (GTEx)

0
1
2
3
4
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
TGF-beta signaling pathwayKEGGko04350
TGF-beta signaling pathwayKEGGhsa04350
Signaling pathways regulating pluripotency of stem cellsKEGGhsa04550
Signaling pathways regulating pluripotency of stem cellsKEGGko04550
Developmental BiologyREACTOMER-HSA-1266738
Signaling by NODALREACTOMER-HSA-1181150
Regulation of signaling by NODALREACTOMER-HSA-1433617

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
385708752024NODAL variants are associated with a continuum of laterality defects from simple D-transposition of the great arteries to heterotaxy.0
385708752024NODAL variants are associated with a continuum of laterality defects from simple D-transposition of the great arteries to heterotaxy.0
350790172022Nodal is a short-range morphogen with activity that spreads through a relay mechanism in human gastruloids.16
353021622022A network of transcription factors governs the dynamics of NODAL/Activin transcriptional responses.3
350790172022Nodal is a short-range morphogen with activity that spreads through a relay mechanism in human gastruloids.16
353021622022A network of transcription factors governs the dynamics of NODAL/Activin transcriptional responses.3
337845902021Embryonic protein NODAL regulates the breast tumor microenvironment by reprogramming cancer-derived secretomes.2
338978752021Nodal-induced L1CAM/CXCR4 subpopulation sustains tumor growth and metastasis in colorectal cancer derived organoids.14
339323192021A case for revisiting Nodal signaling in human pluripotent stem cells.7
344752122021Tril dampens Nodal signaling through Pellino2- and Traf6-mediated activation of Nedd4l.3
346660562021Implication of rare genetic variants of NODAL and ACVR1B in congenital heart disease patients from Indian population.1
347398472021PCSK9 regulates the NODAL signaling pathway and cellular proliferation in hiPSCs.6
347691502021Normal Skin Cells Increase Aggressiveness of Cutaneous Melanoma by Promoting Epithelial-to-Mesenchymal Transition via Nodal and Wnt Activity.3
337845902021Embryonic protein NODAL regulates the breast tumor microenvironment by reprogramming cancer-derived secretomes.2
338978752021Nodal-induced L1CAM/CXCR4 subpopulation sustains tumor growth and metastasis in colorectal cancer derived organoids.14

Citation

Dessen P

NODAL (nodal growth differentiation factor)

Atlas Genet Cytogenet Oncol Haematol. 2007-07-01

Online version: http://atlasgeneticsoncology.org/gene/47626