GSS (glutathione synthetase)

2007-07-01 Affiliation

Identity

HGNC

GSS

LOCATION

20q11.22

LOCUSID

2937

ALIAS

GSHS,HEL-S-64p,HEL-S-88n

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2937
MIM: 601002
HGNC: 4624
Ensembl: ENSG00000100983

Variants:

dbSNP: 2937
ClinVar: 2937
TCGA: ENSG00000100983
COSMIC: GSS

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000100983	ENST00000451957	P48637
ENSG00000100983	ENST00000642493	A0A2R8Y2X9
ENSG00000100983	ENST00000642498	A0A2R8Y430
ENSG00000100983	ENST00000642538	A0A0S2Z4J7
ENSG00000100983	ENST00000643188	P48637
ENSG00000100983	ENST00000643188	V9HWJ1
ENSG00000100983	ENST00000643271	A0A2R8YF34
ENSG00000100983	ENST00000643443	A0A2R8Y6Y6
ENSG00000100983	ENST00000643502	A0A2R8Y5T7
ENSG00000100983	ENST00000644608	A0A2R8Y2F2
ENSG00000100983	ENST00000644793	P48637
ENSG00000100983	ENST00000644793	V9HWJ1
ENSG00000100983	ENST00000645102	A0A2R8Y790
ENSG00000100983	ENST00000645328	A0A2R8Y6Q7
ENSG00000100983	ENST00000645408	A0A2R8Y7I7
ENSG00000100983	ENST00000646405	A0A2R8Y446
ENSG00000100983	ENST00000646735	P48637
ENSG00000100983	ENST00000646766	A0A2R8Y4V9
ENSG00000100983	ENST00000651619	P48637
ENSG00000100983	ENST00000651619	V9HWJ1

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Glutathione metabolism	KEGG	ko00480
Glutathione metabolism	KEGG	hsa00480
Cysteine and methionine metabolism	KEGG	ko00270
Cysteine and methionine metabolism	KEGG	hsa00270
Metabolic pathways	KEGG	hsa01100
Glutathione biosynthesis, glutamate => glutathione	KEGG	hsa_M00118
Glutathione biosynthesis, glutamate => glutathione	KEGG	M00118
Metabolism	REACTOME	R-HSA-1430728
Biological oxidations	REACTOME	R-HSA-211859
Phase II conjugation	REACTOME	R-HSA-156580
Glutathione conjugation	REACTOME	R-HSA-156590
Glutathione synthesis and recycling	REACTOME	R-HSA-174403
Ferroptosis	KEGG	ko04216
Ferroptosis	KEGG	hsa04216

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
31881666	2019	Association of mRNA Levels of IL6, MMP-8, GSS in Saliva and Pyelonephritis in Children.	3
31881666	2019	Association of mRNA Levels of IL6, MMP-8, GSS in Saliva and Pyelonephritis in Children.	3
28849249	2018	Protein levels of clusterin and glutathione synthetase in platelets allow for early detection of colorectal cancer.	11
28849249	2018	Protein levels of clusterin and glutathione synthetase in platelets allow for early detection of colorectal cancer.	11
26669244	2016	Clinical findings and effect of sodium hydrogen carbonate in patients with glutathione synthetase deficiency.	4
26669244	2016	Clinical findings and effect of sodium hydrogen carbonate in patients with glutathione synthetase deficiency.	4
25851338	2015	Genetic Variations in Glutathione Pathway Genes Predict Cancer Recurrence in Patients Treated with Transurethral Resection and Bacillus Calmette-Guerin Instillation for Non-muscle Invasive Bladder Cancer.	15
25851806	2015	Five Chinese patients with 5-oxoprolinuria due to glutathione synthetase and 5-oxoprolinase deficiencies.	4
26059756	2015	Involvement of glutathione and glutathione metabolizing enzymes in human colorectal cancer cell lines and tissues.	21
25851338	2015	Genetic Variations in Glutathione Pathway Genes Predict Cancer Recurrence in Patients Treated with Transurethral Resection and Bacillus Calmette-Guerin Instillation for Non-muscle Invasive Bladder Cancer.	15
25851806	2015	Five Chinese patients with 5-oxoprolinuria due to glutathione synthetase and 5-oxoprolinase deficiencies.	4
26059756	2015	Involvement of glutathione and glutathione metabolizing enzymes in human colorectal cancer cell lines and tissues.	21
24323765	2014	Carnosol, rosemary ingredient, induces apoptosis in adult T-cell leukemia/lymphoma cells via glutathione depletion: proteomic approach using fluorescent two-dimensional differential gel electrophoresis.	10
25070563	2014	The role of strong electrostatic interactions at the dimer interface of human glutathione synthetase.	2
24323765	2014	Carnosol, rosemary ingredient, induces apoptosis in adult T-cell leukemia/lymphoma cells via glutathione depletion: proteomic approach using fluorescent two-dimensional differential gel electrophoresis.	10

Citation

Dessen P

GSS (glutathione synthetase)

Atlas Genet Cytogenet Oncol Haematol. 2007-07-01

Online version: http://atlasgeneticsoncology.org/gene/47630/deep-insight-explorer/css/lib/dataTables.bootstrap.min.css