GSS (glutathione synthetase)

2007-07-01  

Identity

HGNC
GSS
LOCATION
20q11.22
LOCUSID
2937
ALIAS
GSHS,HEL-S-64p,HEL-S-88n
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2937
MIM: 601002
HGNC: 4624
Ensembl: ENSG00000100983

Variants:

dbSNP: 2937
ClinVar: 2937
TCGA: ENSG00000100983
COSMIC: GSS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100983ENST00000451957P48637
ENSG00000100983ENST00000642493A0A2R8Y2X9
ENSG00000100983ENST00000642498A0A2R8Y430
ENSG00000100983ENST00000642538A0A0S2Z4J7
ENSG00000100983ENST00000643188P48637
ENSG00000100983ENST00000643188V9HWJ1
ENSG00000100983ENST00000643271A0A2R8YF34
ENSG00000100983ENST00000643443A0A2R8Y6Y6
ENSG00000100983ENST00000643502A0A2R8Y5T7
ENSG00000100983ENST00000644608A0A2R8Y2F2
ENSG00000100983ENST00000644793P48637
ENSG00000100983ENST00000644793V9HWJ1
ENSG00000100983ENST00000645102A0A2R8Y790
ENSG00000100983ENST00000645328A0A2R8Y6Q7
ENSG00000100983ENST00000645408A0A2R8Y7I7
ENSG00000100983ENST00000646405A0A2R8Y446
ENSG00000100983ENST00000646735P48637
ENSG00000100983ENST00000646766A0A2R8Y4V9
ENSG00000100983ENST00000651619P48637
ENSG00000100983ENST00000651619V9HWJ1

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glutathione metabolismKEGGko00480
Glutathione metabolismKEGGhsa00480
Cysteine and methionine metabolismKEGGko00270
Cysteine and methionine metabolismKEGGhsa00270
Metabolic pathwaysKEGGhsa01100
Glutathione biosynthesis, glutamate => glutathioneKEGGhsa_M00118
Glutathione biosynthesis, glutamate => glutathioneKEGGM00118
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
Glutathione conjugationREACTOMER-HSA-156590
Glutathione synthesis and recyclingREACTOMER-HSA-174403
FerroptosisKEGGko04216
FerroptosisKEGGhsa04216

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
318816662019Association of mRNA Levels of IL6, MMP-8, GSS in Saliva and Pyelonephritis in Children.3
318816662019Association of mRNA Levels of IL6, MMP-8, GSS in Saliva and Pyelonephritis in Children.3
288492492018Protein levels of clusterin and glutathione synthetase in platelets allow for early detection of colorectal cancer.11
288492492018Protein levels of clusterin and glutathione synthetase in platelets allow for early detection of colorectal cancer.11
266692442016Clinical findings and effect of sodium hydrogen carbonate in patients with glutathione synthetase deficiency.4
266692442016Clinical findings and effect of sodium hydrogen carbonate in patients with glutathione synthetase deficiency.4
258513382015Genetic Variations in Glutathione Pathway Genes Predict Cancer Recurrence in Patients Treated with Transurethral Resection and Bacillus Calmette-Guerin Instillation for Non-muscle Invasive Bladder Cancer.15
258518062015Five Chinese patients with 5-oxoprolinuria due to glutathione synthetase and 5-oxoprolinase deficiencies.4
260597562015Involvement of glutathione and glutathione metabolizing enzymes in human colorectal cancer cell lines and tissues.21
258513382015Genetic Variations in Glutathione Pathway Genes Predict Cancer Recurrence in Patients Treated with Transurethral Resection and Bacillus Calmette-Guerin Instillation for Non-muscle Invasive Bladder Cancer.15
258518062015Five Chinese patients with 5-oxoprolinuria due to glutathione synthetase and 5-oxoprolinase deficiencies.4
260597562015Involvement of glutathione and glutathione metabolizing enzymes in human colorectal cancer cell lines and tissues.21
243237652014Carnosol, rosemary ingredient, induces apoptosis in adult T-cell leukemia/lymphoma cells via glutathione depletion: proteomic approach using fluorescent two-dimensional differential gel electrophoresis.10
250705632014The role of strong electrostatic interactions at the dimer interface of human glutathione synthetase.2
243237652014Carnosol, rosemary ingredient, induces apoptosis in adult T-cell leukemia/lymphoma cells via glutathione depletion: proteomic approach using fluorescent two-dimensional differential gel electrophoresis.10

Citation

Dessen P

GSS (glutathione synthetase)

Atlas Genet Cytogenet Oncol Haematol. 2007-07-01

Online version: http://atlasgeneticsoncology.org/gene/47630/gene-explorer/js/lib/jquery-3.5.1.min.js