FCAR (Fc fragment of IgA receptor)

2007-07-01  

Identity

HGNC
LOCATION
19q13.42
LOCUSID
ALIAS
CD89,CTB-61M7.2,FcalphaRI
FUSION GENES

Other Information

Locus ID:

NCBI: 2204
MIM: 147045
HGNC: 3608
Ensembl: ENSG00000186431

Variants:

dbSNP: 2204
ClinVar: 2204
TCGA: ENSG00000186431
COSMIC: FCAR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186431ENST00000345937P24071
ENSG00000186431ENST00000353758P24071
ENSG00000186431ENST00000355524P24071
ENSG00000186431ENST00000359272P24071
ENSG00000186431ENST00000391723P24071
ENSG00000186431ENST00000391724P24071
ENSG00000186431ENST00000391724A0A024R4R4
ENSG00000186431ENST00000391725P24071
ENSG00000186431ENST00000391725A0A024R4N4
ENSG00000186431ENST00000391726P24071
ENSG00000186431ENST00000469767P24071
ENSG00000186431ENST00000469767A0A024R4M5
ENSG00000186431ENST00000488066P24071

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
Staphylococcus aureus infectionKEGGko05150
Staphylococcus aureus infectionKEGGhsa05150
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
378721752023SIgA structures bound to Streptococcus pyogenes M4 and human CD89 provide insights into host-pathogen interactions.0
378721752023SIgA structures bound to Streptococcus pyogenes M4 and human CD89 provide insights into host-pathogen interactions.0
320764662020Serum Soluble CD89-IgA Complexes Are Elevated in IgA Nephropathy without Immunosuppressant History.1
320764662020Serum Soluble CD89-IgA Complexes Are Elevated in IgA Nephropathy without Immunosuppressant History.1
294914062018FcαRI co-stimulation converts human intestinal CD103(+) dendritic cells into pro-inflammatory cells through glycolytic reprogramming.24
294914062018FcαRI co-stimulation converts human intestinal CD103(+) dendritic cells into pro-inflammatory cells through glycolytic reprogramming.24
281031382017Discovery of a novel splice variant of Fcar (CD89) unravels sequence segments necessary for efficient secretion: A story of bad signal peptides and good ones that nevertheless do not make it.4
281031382017Discovery of a novel splice variant of Fcar (CD89) unravels sequence segments necessary for efficient secretion: A story of bad signal peptides and good ones that nevertheless do not make it.4
274379392016Critical Role of Kupffer Cell CD89 Expression in Experimental IgA Nephropathy.11
274379392016Critical Role of Kupffer Cell CD89 Expression in Experimental IgA Nephropathy.11
259077142015Targeted IgA Fc receptor I (FcαRI) therapy in the early intervention and treatment of pristane-induced lupus nephritis in mice.11
259077142015Targeted IgA Fc receptor I (FcαRI) therapy in the early intervention and treatment of pristane-induced lupus nephritis in mice.11
247320612014Expression and correlation analysis of IL-4, IFN-γ and FcαRI in tonsillar mononuclear cells in patients with IgA nephropathy.12
253396722014Human IgA Fc receptor FcαRI (CD89) triggers different forms of neutrophil death depending on the inflammatory microenvironment.15
247320612014Expression and correlation analysis of IL-4, IFN-γ and FcαRI in tonsillar mononuclear cells in patients with IgA nephropathy.12

Citation

Dessen P

FCAR (Fc fragment of IgA receptor)

Atlas Genet Cytogenet Oncol Haematol. 2007-07-01

Online version: http://atlasgeneticsoncology.org/gene/47634/fcar