ARL6IP5 (ADP ribosylation factor like GTPase 6 interacting protein 5)

2007-07-01  

Identity

HGNC
ARL6IP5
LOCATION
3p14.1
LOCUSID
10550
ALIAS
DERP11,GTRAP3-18,HSPC127,JWA,PRAF3,Yip6b,addicsin,hp22,jmx
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10550
MIM: 605709
HGNC: 16937
Ensembl: ENSG00000144746

Variants:

dbSNP: 10550
ClinVar: 10550
TCGA: ENSG00000144746
COSMIC: ARL6IP5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000144746ENST00000273258O75915
ENSG00000144746ENST00000273258A0A024R371
ENSG00000144746ENST00000478935C9JQU6
ENSG00000144746ENST00000484921F8WF33
ENSG00000144746ENST00000485444F8WF90

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Release CycleREACTOMER-HSA-112310
Glutamate Neurotransmitter Release CycleREACTOMER-HSA-210500

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
352933832022ARL6IP5 reduces cisplatin-resistance by suppressing DNA repair and promoting apoptosis pathways in ovarian carcinoma.5
352933832022ARL6IP5 reduces cisplatin-resistance by suppressing DNA repair and promoting apoptosis pathways in ovarian carcinoma.5
317268162021Correlation between JWA gene polymorphism and acute lymphoblastic leukemia.0
317268162021Correlation between JWA gene polymorphism and acute lymphoblastic leukemia.0
294819112018RNF185 modulates JWA ubiquitination and promotes gastric cancer metastasis.18
296585702018JWA suppresses the invasion of human breast carcinoma cells by downregulating the expression of CXCR4.6
294819112018RNF185 modulates JWA ubiquitination and promotes gastric cancer metastasis.18
296585702018JWA suppresses the invasion of human breast carcinoma cells by downregulating the expression of CXCR4.6
284281372017JWA antagonizes paraquat-induced neurotoxicity via activation of Nrf2.11
284281372017JWA antagonizes paraquat-induced neurotoxicity via activation of Nrf2.11
271672062016JWA loss promotes cell migration and cytoskeletal rearrangement by affecting HER2 expression and identifies a high-risk subgroup of HER2-positive gastric carcinoma patients.6
271672062016JWA loss promotes cell migration and cytoskeletal rearrangement by affecting HER2 expression and identifies a high-risk subgroup of HER2-positive gastric carcinoma patients.6
255862712015Effects of the JWA gene in the regulation of human breast cancer cells.6
260466742015EGCG regulates the cross-talk between JWA and topoisomerase IIα in non-small-cell lung cancer (NSCLC) cells.12
255862712015Effects of the JWA gene in the regulation of human breast cancer cells.6

Citation

Dessen P

ARL6IP5 (ADP ribosylation factor like GTPase 6 interacting protein 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-07-01

Online version: http://atlasgeneticsoncology.org/gene/47637/teaching-explorer/gene-fusions/favicon/cancer-prone-explorer/