SPAG1 (sperm associated antigen 1)

2007-07-01 Affiliation

Identity

HGNC

SPAG1

LOCATION

8q22.2

LOCUSID

6674

ALIAS

CILD28,CT140,DNAAF13,HEL-S-268,HSD-3.8,SP75,TPIS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6674
MIM: 603395
HGNC: 11212
Ensembl: ENSG00000104450

Variants:

dbSNP: 6674
ClinVar: 6674
TCGA: ENSG00000104450
COSMIC: SPAG1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000104450	ENST00000251809	Q07617
ENSG00000104450	ENST00000388798	Q07617
ENSG00000104450	ENST00000520508	Q07617
ENSG00000104450	ENST00000520643	Q07617

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
35178554	2022	The role of SPAG1 in the assembly of axonemal dyneins in human airway epithelia.	3
35227274	2022	Comprehensive analysis of SPAG1 expression as a prognostic and predictive biomarker in acute myeloid leukemia by integrative bioinformatics and clinical validation.	4
35951456	2022	SPAG1 promotes the development of AML by activating the ERK/MAPK signaling pathway and affects the chemotherapy sensitivity of venetoclax.	1
35178554	2022	The role of SPAG1 in the assembly of axonemal dyneins in human airway epithelia.	3
35227274	2022	Comprehensive analysis of SPAG1 expression as a prognostic and predictive biomarker in acute myeloid leukemia by integrative bioinformatics and clinical validation.	4
35951456	2022	SPAG1 promotes the development of AML by activating the ERK/MAPK signaling pathway and affects the chemotherapy sensitivity of venetoclax.	1
33739091	2021	Optimizing the First TPR Domain of the Human SPAG1 Protein Provides Insight into the HSP70 and HSP90 Binding Properties.	4
33739091	2021	Optimizing the First TPR Domain of the Human SPAG1 Protein Provides Insight into the HSP70 and HSP90 Binding Properties.	4
32619574	2020	Bioinformatics analysis of the genes involved in the extension of prostate cancer to adjacent lymph nodes by supervised and unsupervised machine learning methods: The role of SPAG1 and PLEKHF2.	11
32619574	2020	Bioinformatics analysis of the genes involved in the extension of prostate cancer to adjacent lymph nodes by supervised and unsupervised machine learning methods: The role of SPAG1 and PLEKHF2.	11
31118266	2019	Binding properties of the quaternary assembly protein SPAG1.	6
31118266	2019	Binding properties of the quaternary assembly protein SPAG1.	6
24055112	2013	Mutations in SPAG1 cause primary ciliary dyskinesia associated with defective outer and inner dynein arms.	74
24055112	2013	Mutations in SPAG1 cause primary ciliary dyskinesia associated with defective outer and inner dynein arms.	74
16983343	2007	Sperm-associated antigen 1 is expressed early in pancreatic tumorigenesis and promotes motility of cancer cells.	15

Citation

Dessen P

SPAG1 (sperm associated antigen 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-07-01

Online version: http://atlasgeneticsoncology.org/gene/47639