Identity
HGNC
LOCATION
1p34.1
LOCUSID
ALIAS
B4Gal-T2,B4Gal-T3,beta4Gal-T2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 8704
MIM: 604013
HGNC: 925
Ensembl: ENSG00000117411
Variants:
dbSNP: 8704
ClinVar: 8704
TCGA: ENSG00000117411
COSMIC: B4GALT2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000117411 | ENST00000309519 | O60909 |
| ENSG00000117411 | ENST00000356836 | O60909 |
| ENSG00000117411 | ENST00000372324 | O60909 |
| ENSG00000117411 | ENST00000434555 | O60909 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA166124406 | platelet reactivity | Disease | VariantAnnotation | associated | PD | ||
| PA443796 | Coronary Artery Disease | Disease | VariantAnnotation | associated | PD | ||
| PA448497 | aspirin | Chemical | VariantAnnotation | associated | PD | ||
| PA449053 | clopidogrel | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 30020015 | 2018 | Beta-1,4-galactosyltransferase 2 c.909C>T gene variant is predictive of on-clopidogrel platelet reactivity. | 1 |
| 30020015 | 2018 | Beta-1,4-galactosyltransferase 2 c.909C>T gene variant is predictive of on-clopidogrel platelet reactivity. | 1 |
| 27004849 | 2016 | Biochemical and functional characterization of glycosylation-associated mutational landscapes in colon cancer. | 28 |
| 27004849 | 2016 | Biochemical and functional characterization of glycosylation-associated mutational landscapes in colon cancer. | 28 |
| 19524017 | 2009 | Site directed processing: role of amino acid sequences and glycosylation of acceptor glycopeptides in the assembly of extended mucin type O-glycan core 2. | 12 |
| 19524017 | 2009 | Site directed processing: role of amino acid sequences and glycosylation of acceptor glycopeptides in the assembly of extended mucin type O-glycan core 2. | 12 |
| 18211920 | 2008 | Identification of beta1,4GalT II as a target gene of p53-mediated HeLa cell apoptosis. | 8 |
| 18211920 | 2008 | Identification of beta1,4GalT II as a target gene of p53-mediated HeLa cell apoptosis. | 8 |
| 17470362 | 2007 | beta4GalT-II increases cisplatin-induced apoptosis in HeLa cells depending on its Golgi localization. | 1 |
| 17470362 | 2007 | beta4GalT-II increases cisplatin-induced apoptosis in HeLa cells depending on its Golgi localization. | 1 |
| 15939404 | 2005 | beta4GalT-II is a key regulator of glycosylation of the proteins involved in neuronal development. | 7 |
| 15939404 | 2005 | beta4GalT-II is a key regulator of glycosylation of the proteins involved in neuronal development. | 7 |
| 15504978 | 2004 | Tumor necrosis factor-alpha in diabetic plasma increases the activity of core 2 GlcNAc-T and adherence of human leukocytes to retinal endothelial cells: significance of core 2 GlcNAc-T in diabetic retinopathy. | 10 |
| 15504978 | 2004 | Tumor necrosis factor-alpha in diabetic plasma increases the activity of core 2 GlcNAc-T and adherence of human leukocytes to retinal endothelial cells: significance of core 2 GlcNAc-T in diabetic retinopathy. | 10 |
Citation
Dessen P
B4GALT2 (beta-1,4-galactosyltransferase 2)
Atlas Genet Cytogenet Oncol Haematol. 2007-08-01
Online version: http://atlasgeneticsoncology.org/gene/47673/b4galt2
