Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9356
MIM: 607582
HGNC: 10970
Ensembl: ENSG00000197901
Variants:
dbSNP: 9356
ClinVar: 9356
TCGA: ENSG00000197901
COSMIC: SLC22A6
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10005 | adefovir dipivoxil | Chemical | Pathway, VariantAnnotation | associated | PK | 15864112, 15914676 | |
| PA10204 | tenofovir | Chemical | Pathway, VariantAnnotation | associated | PK | 15914676 | |
| PA133950441 | hmg coa reductase inhibitors | Chemical | Pathway | associated | |||
| PA134711723 | aminohippurate | Chemical | VariantAnnotation | not associated | 15864112 | ||
| PA166163418 | rucaparib | Chemical | LabelAnnotation | associated | |||
| PA448997 | cidofovir | Chemical | VariantAnnotation | associated | PK | 15914676 | |
| PA450428 | methotrexate | Chemical | Pathway, VariantAnnotation | ambiguous | 15864112, 21317831, 25502615 | ||
| PA451089 | pravastatin | Chemical | Pathway | associated | |||
| PA451954 | zidovudine | Chemical | Pathway | associated | 22960662 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36692015 | 2023 | The kidney drug transporter OAT1 regulates gut microbiome-dependent host metabolism. | 5 |
| 36692015 | 2023 | The kidney drug transporter OAT1 regulates gut microbiome-dependent host metabolism. | 5 |
| 35406626 | 2022 | Functional Characterization of Rare Variants in OAT1/SLC22A6 and OAT3/SLC22A8 Urate Transporters Identified in a Gout and Hyperuricemia Cohort. | 4 |
| 36316339 | 2022 | Drug transporters OAT1 and OAT3 have specific effects on multiple organs and gut microbiome as revealed by contextualized metabolic network reconstructions. | 7 |
| 35406626 | 2022 | Functional Characterization of Rare Variants in OAT1/SLC22A6 and OAT3/SLC22A8 Urate Transporters Identified in a Gout and Hyperuricemia Cohort. | 4 |
| 36316339 | 2022 | Drug transporters OAT1 and OAT3 have specific effects on multiple organs and gut microbiome as revealed by contextualized metabolic network reconstructions. | 7 |
| 31691080 | 2020 | Coadministration of vindesine with high-dose methotrexate therapy increases acute kidney injury via BCRP, MRP2, and OAT1/OAT3. | 4 |
| 32100958 | 2020 | Genetic Diversity in Drug Transporters: Impact in African Populations. | 6 |
| 32818533 | 2020 | Ubiquitin-specific peptidase 8 regulates the trafficking and stability of the human organic anion transporter 1. | 1 |
| 31691080 | 2020 | Coadministration of vindesine with high-dose methotrexate therapy increases acute kidney injury via BCRP, MRP2, and OAT1/OAT3. | 4 |
| 32100958 | 2020 | Genetic Diversity in Drug Transporters: Impact in African Populations. | 6 |
| 32818533 | 2020 | Ubiquitin-specific peptidase 8 regulates the trafficking and stability of the human organic anion transporter 1. | 1 |
| 30653465 | 2019 | Organic anion transporters 1 and 3 influence cellular energy metabolism in renal proximal tubule cells. | 9 |
| 31724834 | 2019 | Estrogen receptor α (ERα) indirectly induces transcription of human renal organic anion transporter 1 (OAT1). | 7 |
| 30653465 | 2019 | Organic anion transporters 1 and 3 influence cellular energy metabolism in renal proximal tubule cells. | 9 |
Citation
Dessen P
SLC22A6 (solute carrier family 22 member 6)
Atlas Genet Cytogenet Oncol Haematol. 2007-08-01
Online version: http://atlasgeneticsoncology.org/gene/47691/slc22a6
