CCAR1 (cell division cycle and apoptosis regulator 1)

2007-08-01  

Identity

HGNC
LOCATION
10q21.3
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 55749
MIM: 612569
HGNC: 24236
Ensembl: ENSG00000060339

Variants:

dbSNP: 55749
ClinVar: 55749
TCGA: ENSG00000060339
COSMIC: CCAR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000060339ENST00000265872Q8IX12
ENSG00000060339ENST00000479143H0YFT7
ENSG00000060339ENST00000494903F5H808
ENSG00000060339ENST00000536012F5H1H2
ENSG00000060339ENST00000536391F5H3I8
ENSG00000060339ENST00000538031F5H7M9
ENSG00000060339ENST00000539539A0A0C4DGG8
ENSG00000060339ENST00000540210F5H3E1
ENSG00000060339ENST00000541012F5H3E1
ENSG00000060339ENST00000543225F5H2E6
ENSG00000060339ENST00000543229F5H1L3
ENSG00000060339ENST00000543706H0YFJ7
ENSG00000060339ENST00000543719Q8IX12
ENSG00000060339ENST00000630771F5H3E1

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
369323872023Exosome-derived circCCAR1 promotes CD8 + T-cell dysfunction and anti-PD1 resistance in hepatocellular carcinoma.56
375633612023m6A-modified circABCC4 promotes stemness and metastasis of prostate cancer by recruiting IGF2BP2 to increase stability of CCAR1.4
369323872023Exosome-derived circCCAR1 promotes CD8 + T-cell dysfunction and anti-PD1 resistance in hepatocellular carcinoma.56
375633612023m6A-modified circABCC4 promotes stemness and metastasis of prostate cancer by recruiting IGF2BP2 to increase stability of CCAR1.4
350404402022Immune responses to CCAR1 and other dermatomyositis autoantigens are associated with attenuated cancer emergence.18
350404402022Immune responses to CCAR1 and other dermatomyositis autoantigens are associated with attenuated cancer emergence.18
320246922020Antagonizing binding of cell cycle and apoptosis regulatory protein 1 (CARP-1) to the NEMO/IKKγ protein enhances the anticancer effect of chemotherapy.4
324223262020MiR-122-5p increases radiosensitivity and aggravates radiation-induced rectal injury through CCAR1.8
329455222020RP11‑284F21.9 promotes lung carcinoma proliferation and invasion via the regulation of miR‑627‑3p/CCAR1.4
320246922020Antagonizing binding of cell cycle and apoptosis regulatory protein 1 (CARP-1) to the NEMO/IKKγ protein enhances the anticancer effect of chemotherapy.4
324223262020MiR-122-5p increases radiosensitivity and aggravates radiation-induced rectal injury through CCAR1.8
329455222020RP11‑284F21.9 promotes lung carcinoma proliferation and invasion via the regulation of miR‑627‑3p/CCAR1.4
303970012019Cell Cycle and Apoptosis Regulator 1, CCAR1, Regulates Enhancer-Dependent Nuclear Receptor CAR Transactivation.2
312814952019Circular RNAs negatively regulate cancer stem cells by physically binding FMRP against CCAR1 complex in hepatocellular carcinoma.130
303970012019Cell Cycle and Apoptosis Regulator 1, CCAR1, Regulates Enhancer-Dependent Nuclear Receptor CAR Transactivation.2

Citation

Dessen P

CCAR1 (cell division cycle and apoptosis regulator 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-08-01

Online version: http://atlasgeneticsoncology.org/gene/47696/ccar1