ARMCX1 (arm protein lost in epithelial cancers, X chromosome, 1)
2003-07-01 Jean-Loup Huret , Sylvie Senon AffiliationGenetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Identity
HGNC
LOCATION
Xq22.1
LOCUSID
ALIAS
ALEX1 (arm protein lost in epithelial cancers, X chromosome, 1)
DNA/RNA
Description
spans 4.2 kb; 4 exons; exon 4 is the only coding exon
Transcription
cDNA: 2141 bp
Proteins
Description
453 amino acids, 49 kDa.; contains a transmembrane domain in N term, an ATP/GTP binding site, 2 arm (armadillo) repeats, and potential phosphorylation sites
Expression
wide in normal tissues, except leucocytes; lost or significantly reduced in carcinomas
Implicated in
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 11162520 | 2001 | ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas. | Kurochkin IV et al |
Other Information
Locus ID:
NCBI: 51309
MIM: 300362
HGNC: 18073
Ensembl: ENSG00000126947
Variants:
dbSNP: 51309
ClinVar: 51309
TCGA: ENSG00000126947
COSMIC: ARMCX1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000126947 | ENST00000372829 | Q9P291 |
| ENSG00000126947 | ENST00000372829 | A0A024RCI6 |
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36726491 | 2023 | The Expression of ARMCX1 in Gastric Cancer Contributes to Prognosis and Influences Chemotherapy. | 0 |
| 36726491 | 2023 | The Expression of ARMCX1 in Gastric Cancer Contributes to Prognosis and Influences Chemotherapy. | 0 |
| 32685472 | 2020 | ARMCX Family Gene Expression Analysis and Potential Prognostic Biomarkers for Prediction of Clinical Outcome in Patients with Gastric Carcinoma. | 9 |
| 32685472 | 2020 | ARMCX Family Gene Expression Analysis and Potential Prognostic Biomarkers for Prediction of Clinical Outcome in Patients with Gastric Carcinoma. | 9 |
| 30907988 | 2019 | miR-106b Promotes Metastasis of Early Gastric Cancer by Targeting ALEX1 in Vitro and in Vivo. | 12 |
| 30907988 | 2019 | miR-106b Promotes Metastasis of Early Gastric Cancer by Targeting ALEX1 in Vitro and in Vivo. | 12 |
| 28315004 | 2018 | ALEX1, a novel tumor suppressor gene, inhibits gastric cancer metastasis via the PAR-1/Rho GTPase signaling pathway. | 12 |
| 28315004 | 2018 | ALEX1, a novel tumor suppressor gene, inhibits gastric cancer metastasis via the PAR-1/Rho GTPase signaling pathway. | 12 |
| 25921134 | 2015 | ALEX1 Regulates Proliferation and Apoptosis in Breast Cancer Cells. | 6 |
| 26464700 | 2015 | ALEX1 may be a novel biomarker for human cervical squamous cell carcinoma. | 5 |
| 25921134 | 2015 | ALEX1 Regulates Proliferation and Apoptosis in Breast Cancer Cells. | 6 |
| 26464700 | 2015 | ALEX1 may be a novel biomarker for human cervical squamous cell carcinoma. | 5 |
| 22494058 | 2012 | ALEX1 suppresses colony formation ability of human colorectal carcinoma cell lines. | 12 |
| 22494058 | 2012 | ALEX1 suppresses colony formation ability of human colorectal carcinoma cell lines. | 12 |
| 20398052 | 2010 | Human Arm protein lost in epithelial cancers, on chromosome X 1 (ALEX1) gene is transcriptionally regulated by CREB and Wnt/beta-catenin signaling. | 13 |
Citation
Jean-Loup Huret ; Sylvie Senon
ARMCX1 (arm protein lost in epithelial cancers, X chromosome, 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-07-01
Online version: http://atlasgeneticsoncology.org/gene/477/armcx1
