ARMCX3 (arm protein lost in epithelial cancers, X chromosome, 3)

2003-07-01   Jean-Loup Huret  , Sylvie Senon  

Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Identity

HGNC
ARMCX3
LOCATION
Xq22.1
LOCUSID
51566
ALIAS
ALEX3 (arm protein lost in epithelial cancers, X chromosome, 3)
FUSION GENES
Show Gene Fusions

DNA/RNA

Description

spans 3.3 kb

Transcription

transcript: 2.0 kb

Proteins

Description

379 amino acids, 42.5 kDa; contains a transmembrane domain in N term, and a arm (armadillo) repeat

Homology

with ALEX1 and ALEX2

Mutations

Note

may be involved in tumorigenesis, but further studies are needed

Implicated in

Article Bibliography

Pubmed IDLast YearTitleAuthors
111625202001ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas.Kurochkin IV et al

Other Information

Locus ID:

NCBI: 51566
MIM: 300364
HGNC: 24065
Ensembl: ENSG00000102401

Variants:

dbSNP: 51566
ClinVar: 51566
TCGA: ENSG00000102401
COSMIC: ARMCX3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102401ENST00000341189Q9UH62
ENSG00000102401ENST00000341189A0A024RCF9
ENSG00000102401ENST00000471229Q9UH62
ENSG00000102401ENST00000471229A0A024RCF9
ENSG00000102401ENST00000479298H3BM63
ENSG00000102401ENST00000491568H3BV87
ENSG00000102401ENST00000537169Q9UH62
ENSG00000102401ENST00000537169A0A024RCF9

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
287051162017Alex3 suppresses non-small cell lung cancer invasion via AKT/Slug/E-cadherin pathway.7
287051162017Alex3 suppresses non-small cell lung cancer invasion via AKT/Slug/E-cadherin pathway.7
238440912013The non-canonical Wnt/PKC pathway regulates mitochondrial dynamics through degradation of the arm-like domain-containing protein Alex3.14
238440912013The non-canonical Wnt/PKC pathway regulates mitochondrial dynamics through degradation of the arm-like domain-containing protein Alex3.14

Citation

Jean-Loup Huret ; Sylvie Senon

ARMCX3 (arm protein lost in epithelial cancers, X chromosome, 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-07-01

Online version: http://atlasgeneticsoncology.org/gene/479