ARMCX3 (arm protein lost in epithelial cancers, X chromosome, 3)
2003-07-01 Jean-Loup Huret , Sylvie Senon AffiliationGenetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Identity
HGNC
LOCATION
Xq22.1
LOCUSID
ALIAS
ALEX3 (arm protein lost in epithelial cancers, X chromosome, 3)
FUSION GENES
DNA/RNA
Description
spans 3.3 kb
Transcription
transcript: 2.0 kb
Proteins
Description
379 amino acids, 42.5 kDa; contains a transmembrane domain in N term, and a arm (armadillo) repeat
Mutations
Note
may be involved in tumorigenesis, but further studies are needed
Implicated in
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 11162520 | 2001 | ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas. | Kurochkin IV et al |
Other Information
Locus ID:
NCBI: 51566
MIM: 300364
HGNC: 24065
Ensembl: ENSG00000102401
Variants:
dbSNP: 51566
ClinVar: 51566
TCGA: ENSG00000102401
COSMIC: ARMCX3
RNA/Proteins
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 28705116 | 2017 | Alex3 suppresses non-small cell lung cancer invasion via AKT/Slug/E-cadherin pathway. | 7 |
| 28705116 | 2017 | Alex3 suppresses non-small cell lung cancer invasion via AKT/Slug/E-cadherin pathway. | 7 |
| 23844091 | 2013 | The non-canonical Wnt/PKC pathway regulates mitochondrial dynamics through degradation of the arm-like domain-containing protein Alex3. | 14 |
| 23844091 | 2013 | The non-canonical Wnt/PKC pathway regulates mitochondrial dynamics through degradation of the arm-like domain-containing protein Alex3. | 14 |
Citation
Jean-Loup Huret ; Sylvie Senon
ARMCX3 (arm protein lost in epithelial cancers, X chromosome, 3)
Atlas Genet Cytogenet Oncol Haematol. 2003-07-01
Online version: http://atlasgeneticsoncology.org/gene/479/armcx3
