CARS (cysteinyj-tRNA synthetase)

2003-08-01 Jean-Loup Huret , Sylvie Senon Affiliation

Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

HGNC

CARS

LOCATION

11p15.4

LOCUSID

833

ALIAS

CARS,CYSRS,MCDDBH,MDBH,MGC:11246

FUSION GENES

Show Gene Fusions

The gene spans 57 kb; 22 exons; 2,5 kb cDNA

alternate splicing

748 amino acids, 85 kDa. Forms homodimers

cytoplasmic

Entity name

Inflammatory myofibroblastic tumors with a complex t(2;11)(p23;p15)

Disease

rare soft tissue tumour found in children and young adults

Prognosis

good prognosis

Hybrid gene

5 CARS - 3 ALK

Fusion protein

N-term CARS (606 amino acids) fused to the usual 562 C-term amino acids of ALK

Pubmed ID	Last Year	Title	Authors
12112524	2002	Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor.	Cools J et al

Jean-Loup Huret ; Sylvie Senon

CARS (cysteinyj-tRNA synthetase)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01