REG4 (regenerating gene type IV)
2003-08-01 Jean-Loup Huret , Sylvie Senon AffiliationGenetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Identity
HGNC
LOCATION
1p12
LOCUSID
ALIAS
GISP,REG-IV,RELP
FUSION GENES
DNA/RNA
Description
the gene spans 17 kb; 1191 bp cDNA; 6 exons; ORF: 474 bp
Proteins
Expression
gastrointestinal tract: stomach, small intestine, colon, and pancreas. High expression inCrohns disease and in ulcerative colitis.
Function
supposed to be involved in cell regeneration and/ or survival
Homology
with other members of the REG family, of which are PSP/REG-I alpha and PAP
Mutations
Somatic
strongly expressed in colorectal tumors as compared to normal colon tissue.
Implicated in
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 11311942 | 2001 | Isolation and characterization of a cDNA encoding a novel member of the human regenerating protein family: Reg IV. | Hartupee JC et al |
| 12455032 | 2003 | Reg IV, a new member of the regenerating gene family, is overexpressed in colorectal carcinomas. | Violette S et al |
Other Information
Locus ID:
NCBI: 83998
MIM: 609846
HGNC: 22977
Ensembl: ENSG00000134193
Variants:
dbSNP: 83998
ClinVar: 83998
TCGA: ENSG00000134193
COSMIC: REG4
RNA/Proteins
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37744296 | 2023 | Regenerating gene 4 promotes chemoresistance of colorectal cancer by affecting lipid droplet synthesis and assembly. | 2 |
| 37744296 | 2023 | Regenerating gene 4 promotes chemoresistance of colorectal cancer by affecting lipid droplet synthesis and assembly. | 2 |
| 34753802 | 2022 | Reg4 Interacts with CD44 to Regulate Proliferation and Stemness of Colorectal and Pancreatic Cancer Cells. | 8 |
| 35929918 | 2022 | The effects of REG4 expression on chemoresistance of ovarian cancer. | 4 |
| 35946046 | 2022 | Upregulation of REG IV gene in human intestinal epithelial cells by lipopolysaccharide via downregulation of microRNA-24. | 7 |
| 34753802 | 2022 | Reg4 Interacts with CD44 to Regulate Proliferation and Stemness of Colorectal and Pancreatic Cancer Cells. | 8 |
| 35929918 | 2022 | The effects of REG4 expression on chemoresistance of ovarian cancer. | 4 |
| 35946046 | 2022 | Upregulation of REG IV gene in human intestinal epithelial cells by lipopolysaccharide via downregulation of microRNA-24. | 7 |
| 33639844 | 2021 | CDX2 and Reg IV expression and correlation in gastric cancer. | 4 |
| 34577861 | 2021 | Clinicopathological Significance and Prognostic Implications of REG4 Immunohistochemical Expression in Colorectal Cancer. | 4 |
| 33639844 | 2021 | CDX2 and Reg IV expression and correlation in gastric cancer. | 4 |
| 34577861 | 2021 | Clinicopathological Significance and Prognostic Implications of REG4 Immunohistochemical Expression in Colorectal Cancer. | 4 |
| 31605540 | 2020 | A mutant KRAS-induced factor REG4 promotes cancer stem cell properties via Wnt/β-catenin signaling. | 23 |
| 31605540 | 2020 | A mutant KRAS-induced factor REG4 promotes cancer stem cell properties via Wnt/β-catenin signaling. | 23 |
| 31428934 | 2019 | REG4 is an indicator for KRAS mutant lung adenocarcinoma with TTF-1 low expression. | 6 |
Citation
Jean-Loup Huret ; Sylvie Senon
REG4 (regenerating gene type IV)
Atlas Genet Cytogenet Oncol Haematol. 2003-08-01
Online version: http://atlasgeneticsoncology.org/gene/485/reg4
