SYNPO2 (synaptopodin 2)

2003-12-01 Jian-Hua Luo Affiliation

Gene Array Laboratory, Univeristy of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

Identity

HGNC

SYNPO2

LOCATION

4q26

LOCUSID

171024

ALIAS

FUSION GENES

Show Gene Fusions

DNA/RNA

Genome structure of myopodin and synaptopodin 2. Green represents exons of myopodin, and orange synaptopodin 2. Introns are indicated with lines.

Description

The genome sequence of myopodin contains 6.8 Kb, while synaptopodin 2 38 kb.

Transcription

A typical messenger RNA of myopodin is 4.2-4.4 kb, and synaptopodin 2 6.7 kb.

Pseudogene

Unknown

Proteins

Protein structure of myopodin and synaptopodin 2. Orange represents sequence unique to synaptopodin 2, Green myopodin. Black stripe represents sequence homologous to synaptopodin 1.

Description

A nuclear localization signal is identified in N-terminus region of myopodin. Myopodin also contains six stretches of homologous sequences with synaptopodin 1.

Expression

Skeletal muscle, prostate, large and small intestine.

Localisation

Nucleus, cytoplasm.

Function

Actin bundling.

Homology

Synaptopodin

Mutations

Germinal

Not known

Somatic

Deletion

Implicated in

Disease

Prostate cancer and urothelial cell carcinoma.

Prognosis

Deletion preferentially occurs in aggressive type of prostate cancer. Loss of expression in nucleus in urothelial cell carcinoma is predictive of poor clinical outcome.

Cytogenetics

Not known

Article Bibliography

Pubmed ID	Last Year	Title	Authors
11696420	2001	Myopodin, a synaptopodin homologue, is frequently deleted in invasive prostate cancers.	Lin F et al
12917631	2003	Tumor suppressor role for myopodin in bladder cancer: loss of nuclear expression of myopodin is cell-cycle dependent and predicts clinical outcome.	Sanchez-Carbayo M et al
11673475	2001	Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein.	Weins A et al

Other Information

Locus ID:

NCBI: 171024
HGNC: 17732
Ensembl: ENSG00000172403

Variants:

dbSNP: 171024
ClinVar: 171024
TCGA: ENSG00000172403
COSMIC: SYNPO2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000172403	ENST00000307142	Q9UMS6
ENSG00000172403	ENST00000429713	Q9UMS6
ENSG00000172403	ENST00000434046	Q9UMS6
ENSG00000172403	ENST00000448416	B4E258
ENSG00000172403	ENST00000504178	H0Y9Y3
ENSG00000172403	ENST00000610556	Q9UMS6
ENSG00000172403	ENST00000627783	Q9UMS6
ENSG00000172403	ENST00000627783	B4DLE4

Expression (GTEx)

100

200

300

400

500

600

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
38038167	2024	SYNPO2 promotes the development of BLCA by upregulating the infiltration of resting mast cells and increasing the resistance to immunotherapy.	0
38038167	2024	SYNPO2 promotes the development of BLCA by upregulating the infiltration of resting mast cells and increasing the resistance to immunotherapy.	0
38201288	2023	Synaptopodin-2 Isoforms Have Specific Binding Partners and Display Distinct, Muscle Cell Type-Specific Expression Patterns.	0
38201288	2023	Synaptopodin-2 Isoforms Have Specific Binding Partners and Display Distinct, Muscle Cell Type-Specific Expression Patterns.	0
34333382	2021	SYNPO2 suppresses hypoxia-induced proliferation and migration of colorectal cancer cells by regulating YAP-KLF5 axis.	8
34333382	2021	SYNPO2 suppresses hypoxia-induced proliferation and migration of colorectal cancer cells by regulating YAP-KLF5 axis.	8
32278815	2020	Synaptopodin-2 promotes hepatocellular carcinoma metastasis via calcineurin-induced nuclear-cytoplasmic translocation.	8
32278815	2020	Synaptopodin-2 promotes hepatocellular carcinoma metastasis via calcineurin-induced nuclear-cytoplasmic translocation.	8
28991374	2018	Synaptopodin-2 suppresses metastasis of triple-negative breast cancer via inhibition of YAP/TAZ activity.	28
28991374	2018	Synaptopodin-2 suppresses metastasis of triple-negative breast cancer via inhibition of YAP/TAZ activity.	28
28231729	2017	Association of a common variant of SYNPO2 gene with increased risk of serous epithelial ovarian cancer.	3
28231729	2017	Association of a common variant of SYNPO2 gene with increased risk of serous epithelial ovarian cancer.	3
27470516	2016	Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of LMOD1, SYNPO2, PDLIM7, PLN, and SYNM.	40
27592258	2016	Myopodin methylation is a prognostic biomarker and predicts antiangiogenic response in advanced kidney cancer.	6
27470516	2016	Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of LMOD1, SYNPO2, PDLIM7, PLN, and SYNM.	40

Citation

Jian-Hua Luo

SYNPO2 (synaptopodin 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/488/synpo2