ABI2 (abl interactor 2)

2003-02-01  

Identity

HGNC
ABI2
LOCATION
2q33.2
LOCUSID
10152
ALIAS
ABI-2,ABI2B,AIP-1,AIP1,AblBP3,SSH3BP2,argBP1,argBPIA,argBPIB
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10152
MIM: 606442
HGNC: 24011
Ensembl: ENSG00000138443

Variants:

dbSNP: 10152
ClinVar: 10152
TCGA: ENSG00000138443
COSMIC: ABI2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138443ENST00000261016B7Z836
ENSG00000138443ENST00000261017Q9NYB9
ENSG00000138443ENST00000261018F8WAL6
ENSG00000138443ENST00000295851F8WAL6
ENSG00000138443ENST00000413635F8WAU3
ENSG00000138443ENST00000416001F8WBL5
ENSG00000138443ENST00000417864E7EP65
ENSG00000138443ENST00000422511E7EW77
ENSG00000138443ENST00000424558A0A0C4DG21
ENSG00000138443ENST00000425253F8WCD7
ENSG00000138443ENST00000430418E9PEZ7
ENSG00000138443ENST00000431886F8WEB9
ENSG00000138443ENST00000441061F8WAQ3
ENSG00000138443ENST00000444584E7EUA1
ENSG00000138443ENST00000447762F8WAZ8
ENSG00000138443ENST00000451591H7C3Q7
ENSG00000138443ENST00000454023H0Y6B5

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Regulation of actin cytoskeletonKEGGko04810
Regulation of actin cytoskeletonKEGGhsa04810
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
Regulation of actin dynamics for phagocytic cup formationREACTOMER-HSA-2029482
Signal TransductionREACTOMER-HSA-162582
Signaling by VEGFREACTOMER-HSA-194138
VEGFA-VEGFR2 PathwayREACTOMER-HSA-4420097
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate WASPs and WAVEsREACTOMER-HSA-5663213

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
370428422023PIM1 phosphorylates ABI2 to enhance actin dynamics and promote tumor invasion.3
370428422023PIM1 phosphorylates ABI2 to enhance actin dynamics and promote tumor invasion.3
324966562020Association of Abl interactor 2, ABI2, with platelet/lymphocyte ratio in patients with renal cell carcinoma: A pilot study.2
324966562020Association of Abl interactor 2, ABI2, with platelet/lymphocyte ratio in patients with renal cell carcinoma: A pilot study.2
279323142017TIS21(/BTG2) inhibits doxorubicin-induced stress fiber-vimentin networks via Nox4-ROS-ABI2-DRF-linked signal cascade.2
279323142017TIS21(/BTG2) inhibits doxorubicin-induced stress fiber-vimentin networks via Nox4-ROS-ABI2-DRF-linked signal cascade.2
223048322012Abl-interactor 2 (ABI2): a novel MLL translocation partner in acute myeloid leukemia.4
223048322012Abl-interactor 2 (ABI2): a novel MLL translocation partner in acute myeloid leukemia.4
191582782009Regulation of cell-cell adhesion by Abi/Diaphanous complexes.63
191582782009Regulation of cell-cell adhesion by Abi/Diaphanous complexes.63
186326092008Tripartite motif protein 32 facilitates cell growth and migration via degradation of Abl-interactor 2.59
186326092008Tripartite motif protein 32 facilitates cell growth and migration via degradation of Abl-interactor 2.59
173896882007Bcr-Abl induces abnormal cytoskeleton remodeling, beta1 integrin clustering and increased cell adhesion to fibronectin through the Abl interactor 1 pathway.26
173896882007Bcr-Abl induces abnormal cytoskeleton remodeling, beta1 integrin clustering and increased cell adhesion to fibronectin through the Abl interactor 1 pathway.26
164889062006The expression of Abl interactor 2 in leiomyoma and myometrium and regulation by GnRH analogue and transforming growth factor-beta.1

Citation

Dessen P

ABI2 (abl interactor 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/494/img/haematological-explorer/favicon/favicon-32x32.png