DLX3 (distal-less homeobox 3)

2007-09-01  

Identity

HGNC
DLX3
LOCATION
17q21.33
LOCUSID
1747
ALIAS
AI4,TDO

Other Information

Locus ID:

NCBI: 1747
MIM: 600525
HGNC: 2916
Ensembl: ENSG00000064195

Variants:

dbSNP: 1747
ClinVar: 1747
TCGA: ENSG00000064195
COSMIC: DLX3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000064195ENST00000434704O60479
ENSG00000064195ENST00000512495F8VXG1

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
380067132024A novel DLX3 mutation causes tricho-dento-osseous syndrome with abnormal enamel structure and formation.0
380067132024A novel DLX3 mutation causes tricho-dento-osseous syndrome with abnormal enamel structure and formation.0
368543472023A heterozygous missense variant in DLX3 leads to uterine leiomyomas and pregnancy losses in a consanguineous Iranian family.0
368543472023A heterozygous missense variant in DLX3 leads to uterine leiomyomas and pregnancy losses in a consanguineous Iranian family.0
357144412022Novel DLX3 variant identified in a family with tricho-dento-osseous syndrome.1
360127532022Salt Dependence of DNA Binding Activity of Human Transcription Factor Dlx3.2
357144412022Novel DLX3 variant identified in a family with tricho-dento-osseous syndrome.1
360127532022Salt Dependence of DNA Binding Activity of Human Transcription Factor Dlx3.2
336553302021Effects of DLX3 on the osteogenic differentiation of induced pluripotent stem cell‑derived mesenchymal stem cells.6
339479612021Loss of DLX3 tumor suppressive function promotes progression of SCC through EGFR-ERBB2 pathway.2
349252252021The miR-4739/DLX3 Axis Modulates Bone Marrow-Derived Mesenchymal Stem Cell (BMSC) Osteogenesis Affecting Osteoporosis Progression.4
336553302021Effects of DLX3 on the osteogenic differentiation of induced pluripotent stem cell‑derived mesenchymal stem cells.6
339479612021Loss of DLX3 tumor suppressive function promotes progression of SCC through EGFR-ERBB2 pathway.2
349252252021The miR-4739/DLX3 Axis Modulates Bone Marrow-Derived Mesenchymal Stem Cell (BMSC) Osteogenesis Affecting Osteoporosis Progression.4
300952082019Novel DLX3 variants in amelogenesis imperfecta with attenuated tricho-dento-osseous syndrome.12

Citation

Dessen P

DLX3 (distal-less homeobox 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-09-01

Online version: http://atlasgeneticsoncology.org/gene/49723