PARD3 (par-3 family cell polarity regulator)

2007-10-01  

Identity

HGNC
PARD3
LOCATION
10p11.22
LOCUSID
56288
ALIAS
ASIP,Baz,PAR3,PAR3alpha,PARD-3,PARD3A,PPP1R118,SE2-5L16,SE2-5LT1,SE2-5T2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 56288
MIM: 606745
HGNC: 16051
Ensembl: ENSG00000148498

Variants:

dbSNP: 56288
ClinVar: 56288
TCGA: ENSG00000148498
COSMIC: PARD3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000148498ENST00000340077Q8TEW0
ENSG00000148498ENST00000346874Q8TEW0
ENSG00000148498ENST00000350537Q8TEW0
ENSG00000148498ENST00000374768B1AP52
ENSG00000148498ENST00000374773Q5VWU8
ENSG00000148498ENST00000374776Q8TEW0
ENSG00000148498ENST00000374788Q8TEW0
ENSG00000148498ENST00000374789Q8TEW0
ENSG00000148498ENST00000374790Q5VWV2
ENSG00000148498ENST00000374794Q8TEW0
ENSG00000148498ENST00000544292F5GZI3
ENSG00000148498ENST00000545260Q8TEW0
ENSG00000148498ENST00000545693Q8TEW0

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Axon guidanceKEGGko04360
Adherens junctionKEGGko04520
Tight junctionKEGGko04530
Neuroactive ligand-receptor interactionKEGGhsa04080
Axon guidanceKEGGhsa04360
Adherens junctionKEGGhsa04520
Tight junctionKEGGhsa04530
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Signal TransductionREACTOMER-HSA-162582
Signaling by TGF-beta Receptor ComplexREACTOMER-HSA-170834
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)REACTOMER-HSA-2173791
Cell-Cell communicationREACTOMER-HSA-1500931
Cell junction organizationREACTOMER-HSA-446728
Cell-cell junction organizationREACTOMER-HSA-421270
Tight junction interactionsREACTOMER-HSA-420029

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383171862024PARD3 drives tumorigenesis through activating Sonic Hedgehog signalling in tumour-initiating cells in liver cancer.3
387110822024DCAF1 interacts with PARD3 to promote hepatocellular carcinoma progression and metastasis by activating the Akt signaling pathway.0
383171862024PARD3 drives tumorigenesis through activating Sonic Hedgehog signalling in tumour-initiating cells in liver cancer.3
387110822024DCAF1 interacts with PARD3 to promote hepatocellular carcinoma progression and metastasis by activating the Akt signaling pathway.0
372320352023Integrative analysis of cancer dependency data and comprehensive phosphoproteomics data revealed the EPHA2-PARD3 axis as a cancer vulnerability in KRAS-mutant colorectal cancer.1
372320352023Integrative analysis of cancer dependency data and comprehensive phosphoproteomics data revealed the EPHA2-PARD3 axis as a cancer vulnerability in KRAS-mutant colorectal cancer.1
335657142022Par-3 family proteins in cell polarity & adhesion.11
350799812022Polarity protein Par3 sensitizes breast cancer to paclitaxel by promoting cell cycle arrest.1
335657142022Par-3 family proteins in cell polarity & adhesion.11
350799812022Polarity protein Par3 sensitizes breast cancer to paclitaxel by promoting cell cycle arrest.1
336756512021Par3/integrin β1 regulates embryo adhesion via changing endometrial luminal epithelium polarity†.0
339319212021Loss of polarity protein Par3, via transcription factor Snail, promotes bladder cancer metastasis.4
340237832021Loss of polarity protein Par3 is mediated by transcription factor Sp1 in breast cancer.2
340400992021High expression of PARD3 predicts poor prognosis in hepatocellular carcinoma.6
342164862021Par3 and ZO-1 Membrane Clustering is an Indicator of Poor Prognosis in Lung Squamous Cell Carcinoma.1

Citation

Dessen P

PARD3 (par-3 family cell polarity regulator)

Atlas Genet Cytogenet Oncol Haematol. 2007-10-01

Online version: http://atlasgeneticsoncology.org/gene/49754/js/lib/js/lib/js/template.js