USP18 (ubiquitin specific peptidase 18)

2007-10-01  

Identity

HGNC
USP18
LOCATION
22q11.21
LOCUSID
11274
ALIAS
ISG43,PTORCH2,UBP43
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11274
MIM: 607057
HGNC: 12616
Ensembl: ENSG00000184979

Variants:

dbSNP: 11274
ClinVar: 11274
TCGA: ENSG00000184979
COSMIC: USP18

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000184979ENST00000215794Q9UMW8

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon alpha/beta signalingREACTOMER-HSA-909733
Regulation of IFNA signalingREACTOMER-HSA-912694
Antiviral mechanism by IFN-stimulated genesREACTOMER-HSA-1169410
ISG15 antiviral mechanismREACTOMER-HSA-1169408
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA36184STAT2GenePathwayassociated26111151

References

Pubmed IDYearTitleCitations
376255432024ISG15-USP18 Dysregulation by Oxidative Stress Promotes IFN-γ Secretion from CD8+ T Cells in Vitiligo.2
386913022024USP18 Curbs the Progression of Metabolic Hypertension by Suppressing JAK/STAT Pathway.0
376255432024ISG15-USP18 Dysregulation by Oxidative Stress Promotes IFN-γ Secretion from CD8+ T Cells in Vitiligo.2
386913022024USP18 Curbs the Progression of Metabolic Hypertension by Suppressing JAK/STAT Pathway.0
366467042023Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis.18
371864332023UBP43 promotes epithelial ovarian carcinogenesis via activation of β-catenin signaling pathway.0
372572452023USP18 regulates the malignant phenotypes of glioblastoma stem cells.2
374229302023USP18 promotes innate immune responses and apoptosis in influenza A virus-infected A549 cells via cGAS-STING pathway.1
374422662023Tumor-promoting action of ubiquitin protease 43 in gastric cancer progression through deubiquitination and stabilization of stress-inducible phosphoprotein 1.0
375064912023Genome-wide DNA methylation analysis implicates enrichment of interferon pathway in African American patients with Systemic Lupus Erythematosus and European Americans with lupus nephritis.0
366467042023Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis.18
371864332023UBP43 promotes epithelial ovarian carcinogenesis via activation of β-catenin signaling pathway.0
372572452023USP18 regulates the malignant phenotypes of glioblastoma stem cells.2
374229302023USP18 promotes innate immune responses and apoptosis in influenza A virus-infected A549 cells via cGAS-STING pathway.1
374422662023Tumor-promoting action of ubiquitin protease 43 in gastric cancer progression through deubiquitination and stabilization of stress-inducible phosphoprotein 1.0

Citation

Dessen P

USP18 (ubiquitin specific peptidase 18)

Atlas Genet Cytogenet Oncol Haematol. 2007-10-01

Online version: http://atlasgeneticsoncology.org/gene/49760/gene-fusions/cancer-prone-explorer/js/lib/jquery-3.5.1.min.js