Identity
HGNC
LOCATION
9p24.2
LOCUSID
ALIAS
DCBXA,EAAC1,EAAT3,SCZD18
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 6505
MIM: 133550
HGNC: 10939
Ensembl: ENSG00000106688
Variants:
dbSNP: 6505
ClinVar: 6505
TCGA: ENSG00000106688
COSMIC: SLC1A1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000106688 | ENST00000262352 | P43005 |
| ENSG00000106688 | ENST00000422398 | H0Y7R2 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164713257 | Selective serotonin reuptake inhibitors | Chemical | ClinicalAnnotation | associated | PD | 22776887 | |
| PA447211 | Obsessive-Compulsive Disorder | Disease | ClinicalAnnotation | associated | PD | 22776887 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36344769 | 2023 | Epstein-Barr virus infection controls the concentration of the intracellular antioxidant glutathione by upregulation of the glutamate transporter EAAT3 in tumor cells. | 0 |
| 36344769 | 2023 | Epstein-Barr virus infection controls the concentration of the intracellular antioxidant glutathione by upregulation of the glutamate transporter EAAT3 in tumor cells. | 0 |
| 33390475 | 2021 | [The neuroprotective role of EAAC1 in hippocampal injury following ischemia-reperfusion]. | 0 |
| 33658209 | 2021 | Cryo-EM structures of excitatory amino acid transporter 3 visualize coupled substrate, sodium, and proton binding and transport. | 24 |
| 34628354 | 2021 | SLC1A1 mediated glutamine addiction and contributed to natural killer T-cell lymphoma progression with immunotherapeutic potential. | 12 |
| 33390475 | 2021 | [The neuroprotective role of EAAC1 in hippocampal injury following ischemia-reperfusion]. | 0 |
| 33658209 | 2021 | Cryo-EM structures of excitatory amino acid transporter 3 visualize coupled substrate, sodium, and proton binding and transport. | 24 |
| 34628354 | 2021 | SLC1A1 mediated glutamine addiction and contributed to natural killer T-cell lymphoma progression with immunotherapeutic potential. | 12 |
| 31985241 | 2020 | Association of SLC1A1 gene polymorphism with obsessive compulsive disorder in a sample from southern India. | 0 |
| 32566650 | 2020 | SLC1A1, SLC16A9, and CNTN3 Are Potential Biomarkers for the Occurrence of Colorectal Cancer. | 7 |
| 32827867 | 2020 | NCX1 and EAAC1 transporters are involved in the protective action of glutamate in an in vitro Alzheimer's disease-like model. | 8 |
| 32899900 | 2020 | Gateways for Glutamate Neuroprotection in Parkinson's Disease (PD): Essential Role of EAAT3 and NCX1 Revealed in an In Vitro Model of PD. | 6 |
| 33187547 | 2020 | Neuregulin-1 inhibits CoCl(2)-induced upregulation of excitatory amino acid carrier 1 expression and oxidative stress in SH-SY5Y cells and the hippocampus of mice. | 5 |
| 31985241 | 2020 | Association of SLC1A1 gene polymorphism with obsessive compulsive disorder in a sample from southern India. | 0 |
| 32566650 | 2020 | SLC1A1, SLC16A9, and CNTN3 Are Potential Biomarkers for the Occurrence of Colorectal Cancer. | 7 |
Citation
Dessen P
SLC1A1 (solute carrier family 1 member 1)
Atlas Genet Cytogenet Oncol Haematol. 2007-10-01
Online version: http://atlasgeneticsoncology.org/gene/49772/slc1a1
