RDH10 (retinol dehydrogenase 10)

2007-11-01  

Identity

HGNC
RDH10
LOCATION
8q21.11
LOCUSID
157506
ALIAS
SDR16C4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 157506
MIM: 607599
HGNC: 19975
Ensembl: ENSG00000121039

Variants:

dbSNP: 157506
ClinVar: 157506
TCGA: ENSG00000121039
COSMIC: RDH10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000121039ENST00000240285Q8IZV5
ENSG00000121039ENST00000240285A0A024R7X6
ENSG00000121039ENST00000519380E5RK48
ENSG00000121039ENST00000521928E5RHJ9

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Retinol metabolismKEGGko00830
Retinol metabolismKEGGhsa00830
Metabolic pathwaysKEGGhsa01100
Signal TransductionREACTOMER-HSA-162582
Visual phototransductionREACTOMER-HSA-2187338
The canonical retinoid cycle in rods (twilight vision)REACTOMER-HSA-2453902
Signaling by Retinoic AcidREACTOMER-HSA-5362517
RA biosynthesis pathwayREACTOMER-HSA-5365859

References

Pubmed IDYearTitleCitations
356348472022Retinol dehydrogenase 10 contributes to cancer stemness and intracellular carbohydrate storage in ovarian clear cell carcinomas.0
356348472022Retinol dehydrogenase 10 contributes to cancer stemness and intracellular carbohydrate storage in ovarian clear cell carcinomas.0
334859672021Changes in retinoid metabolism and signaling associated with metabolic remodeling during fasting and in type I diabetes.10
334859672021Changes in retinoid metabolism and signaling associated with metabolic remodeling during fasting and in type I diabetes.10
316138212019Retinol dehydrogenase 10 promotes metastasis of glioma cells via the transforming growth factor-β/SMAD signaling pathway.3
316138212019Retinol dehydrogenase 10 promotes metastasis of glioma cells via the transforming growth factor-β/SMAD signaling pathway.3
277936052017Characterization of human short chain dehydrogenase/reductase SDR16C family members related to retinol dehydrogenase 10.17
281693992017Rdh10 loss-of-function and perturbed retinoid signaling underlies the etiology of choanal atresia.11
282324912017The antagonistically bifunctional retinoid oxidoreductase complex is required for maintenance of all-trans-retinoic acid homeostasis.17
277936052017Characterization of human short chain dehydrogenase/reductase SDR16C family members related to retinol dehydrogenase 10.17
281693992017Rdh10 loss-of-function and perturbed retinoid signaling underlies the etiology of choanal atresia.11
282324912017The antagonistically bifunctional retinoid oxidoreductase complex is required for maintenance of all-trans-retinoic acid homeostasis.17
306955882016[[Gene expression of key enzymes for all-trans- retinoic acid biosynthesis - ALDHJAI and RDH10: relationship with co-expression of nuclear receptors RARα and PPARβ/δ genes and some clinical characteristics in multiple myeloma].1
306955882016[[Gene expression of key enzymes for all-trans- retinoic acid biosynthesis - ALDHJAI and RDH10: relationship with co-expression of nuclear receptors RARα and PPARβ/δ genes and some clinical characteristics in multiple myeloma].1
256276862015Insulin regulates retinol dehydrogenase expression and all-trans-retinoic acid biosynthesis through FoxO1.28

Citation

Dessen P

RDH10 (retinol dehydrogenase 10)

Atlas Genet Cytogenet Oncol Haematol. 2007-11-01

Online version: http://atlasgeneticsoncology.org/gene/49788/meetings/haematological-explorer/haematological-explorer/