CLDN8 (claudin 8)

2007-11-01  

Identity

HGNC
LOCATION
21q22.11
LOCUSID
ALIAS
HEL-S-79

Other Information

Locus ID:

NCBI: 9073
MIM: 611231
HGNC: 2050
Ensembl: ENSG00000156284

Variants:

dbSNP: 9073
ClinVar: 9073
TCGA: ENSG00000156284
COSMIC: CLDN8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156284ENST00000399899P56748
ENSG00000156284ENST00000399899A0A0K0K1I9

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Tight junctionKEGGko04530
Leukocyte transendothelial migrationKEGGko04670
Cell adhesion molecules (CAMs)KEGGhsa04514
Tight junctionKEGGhsa04530
Leukocyte transendothelial migrationKEGGhsa04670
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
Cell-Cell communicationREACTOMER-HSA-1500931
Cell junction organizationREACTOMER-HSA-446728
Cell-cell junction organizationREACTOMER-HSA-421270
Tight junction interactionsREACTOMER-HSA-420029

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
319360442020Campylobacter concisus Impairs Sodium Absorption in Colonic Epithelium via ENaC Dysfunction and Claudin-8 Disruption.12
319360442020Campylobacter concisus Impairs Sodium Absorption in Colonic Epithelium via ENaC Dysfunction and Claudin-8 Disruption.12
311155532019Identification of claudin‑1, ‑3, ‑7 and ‑8 as prognostic markers in human laryngeal carcinoma.13
311612662019MiR-361-5p inhibits cell proliferation and induces cell apoptosis in retinoblastoma by negatively regulating CLDN8.9
315261982019Identification of key genes and pathways associated with Crohn's disease by bioinformatics analysis.1
311155532019Identification of claudin‑1, ‑3, ‑7 and ‑8 as prognostic markers in human laryngeal carcinoma.13
311612662019MiR-361-5p inhibits cell proliferation and induces cell apoptosis in retinoblastoma by negatively regulating CLDN8.9
315261982019Identification of key genes and pathways associated with Crohn's disease by bioinformatics analysis.1
297880922018Cytokine IL9 Triggers the Pathogenesis of Inflammatory Bowel Disease Through the miR21-CLDN8 Pathway.12
299011882018Differences in the expression profiles of claudin proteins in human gastric carcinoma compared with non‑neoplastic mucosa.15
297880922018Cytokine IL9 Triggers the Pathogenesis of Inflammatory Bowel Disease Through the miR21-CLDN8 Pathway.12
299011882018Differences in the expression profiles of claudin proteins in human gastric carcinoma compared with non‑neoplastic mucosa.15
281387552017Epithelial barrier dysfunction in lymphocytic colitis through cytokine-dependent internalization of claudin-5 and -8.14
284748052017CLDN8, an androgen-regulated gene, promotes prostate cancer cell proliferation and migration.21
291454222017Missense mutation at CLDN8 associated with a high plasma interferon gamma-inducible protein 10 level in methadone-maintained patients with urine test positive for morphine.2

Citation

Dessen P

CLDN8 (claudin 8)

Atlas Genet Cytogenet Oncol Haematol. 2007-11-01

Online version: http://atlasgeneticsoncology.org/gene/49807/cldn8