Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4986
MIM: 165196
HGNC: 8154
Ensembl: ENSG00000082556
Variants:
dbSNP: 4986
ClinVar: 4986
TCGA: ENSG00000082556
COSMIC: OPRK1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA166128095 | treatment failure | Disease | VariantAnnotation | associated | PD | 27472837 | |
| PA443309 | Alcoholism | Disease | ClinicalAnnotation | associated | PD | ||
| PA444460 | Heroin Dependence | Disease | ClinicalAnnotation | associated | PD | 17373729, 31940240 | |
| PA445043 | Opioid-Related Disorders | Disease | VariantAnnotation | not associated | |||
| PA445062 | Neoplasms | Disease | ClinicalAnnotation, VariantAnnotation | associated | PD | 27472837, 29259946 | |
| PA445208 | Pain | Disease | ClinicalAnnotation, VariantAnnotation | associated | PD | 27472837, 29259946 | |
| PA448073 | ethanol | Chemical | ClinicalAnnotation | associated | PD | ||
| PA450401 | methadone | Chemical | ClinicalAnnotation | associated | PD | 31940240 | |
| PA450550 | morphine | Chemical | ClinicalAnnotation | associated | PD | 29259946 | |
| PA450741 | oxycodone | Chemical | VariantAnnotation | associated | PD | 27472837 | |
| PA452618 | opioids | Chemical | MultilinkAnnotation, VariantAnnotation | ambiguous | 27139154 | ||
| PA452619 | heroin | Chemical | ClinicalAnnotation | associated | PD | 17373729 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38013468 | 2024 | κ-Opioid receptor activation attenuates osteoarthritis synovitis by regulating macrophage polarization through the NF-κB pathway. | 2 |
| 38013468 | 2024 | κ-Opioid receptor activation attenuates osteoarthritis synovitis by regulating macrophage polarization through the NF-κB pathway. | 2 |
| 36695971 | 2023 | Clustering of KOR PET images separates people with AUD into distinct responses to naltrexone. | 0 |
| 37177778 | 2023 | Effect of PDYN and OPRK1 polymorphisms on the risk of alcohol use disorder and the intensity of depressive symptoms. | 0 |
| 36695971 | 2023 | Clustering of KOR PET images separates people with AUD into distinct responses to naltrexone. | 0 |
| 37177778 | 2023 | Effect of PDYN and OPRK1 polymorphisms on the risk of alcohol use disorder and the intensity of depressive symptoms. | 0 |
| 34843875 | 2022 | Analyses of polymorphisms of intron 2 of OPRK1 (kappa-opioid receptor gene) in association with opioid and cocaine dependence diagnoses in an African-American population. | 1 |
| 34878160 | 2022 | Opioids in cancer: The κ‑opioid receptor (Review). | 2 |
| 36463243 | 2022 | The dynorphin/kappa opioid receptor mediates adverse immunological and behavioral outcomes induced by repetitive blast trauma. | 0 |
| 34843875 | 2022 | Analyses of polymorphisms of intron 2 of OPRK1 (kappa-opioid receptor gene) in association with opioid and cocaine dependence diagnoses in an African-American population. | 1 |
| 34878160 | 2022 | Opioids in cancer: The κ‑opioid receptor (Review). | 2 |
| 36463243 | 2022 | The dynorphin/kappa opioid receptor mediates adverse immunological and behavioral outcomes induced by repetitive blast trauma. | 0 |
| 32508243 | 2021 | Haplotype-based association study of Opioid Receptor Kappa-type 1 (OPRK1) gene polymorphisms with nicotine dependence among male smokers. | 0 |
| 32541931 | 2021 | Occupancy of the kappa opioid receptor by naltrexone predicts reduction in drinking and craving. | 11 |
| 34332276 | 2021 | Activation of κ-opioid receptor inhibits inflammatory response induced by sodium palmitate in human umbilical vein endothelial cells. | 2 |
Citation
Dessen P
OPRK1 (opioid receptor kappa 1)
Atlas Genet Cytogenet Oncol Haematol. 2007-11-01
Online version: http://atlasgeneticsoncology.org/gene/49809/oprk1
