HJURP (Holliday junction recognition protein)

2007-11-01  

Identity

HGNC
HJURP
LOCATION
2q37.1
LOCUSID
55355
ALIAS
FAKTS,URLC9,hFLEG1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55355
MIM: 612667
HGNC: 25444
Ensembl: ENSG00000123485

Variants:

dbSNP: 55355
ClinVar: 55355
TCGA: ENSG00000123485
COSMIC: HJURP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000123485ENST00000411486Q8NCD3
ENSG00000123485ENST00000414924C9JWC4
ENSG00000123485ENST00000432087Q8NCD3
ENSG00000123485ENST00000433484H7C0I6
ENSG00000123485ENST00000441687Q8NCD3
ENSG00000123485ENST00000453122F8WCV1
ENSG00000123485ENST00000454020H7C3V8

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
Chromosome MaintenanceREACTOMER-HSA-73886
Nucleosome assemblyREACTOMER-HSA-774815
Deposition of new CENPA-containing nucleosomes at the centromereREACTOMER-HSA-606279

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382790622024HJURP is recruited to double-strand break sites and facilitates DNA repair by promoting chromatin reorganization.0
385613842024Identification of ASF1A and HJURP by global H3-H4 histone chaperone analysis as a prognostic two-gene model in hepatocellular carcinoma.0
382790622024HJURP is recruited to double-strand break sites and facilitates DNA repair by promoting chromatin reorganization.0
385613842024Identification of ASF1A and HJURP by global H3-H4 histone chaperone analysis as a prognostic two-gene model in hepatocellular carcinoma.0
378487562023NFE2L1 restrains ferroptosis by transcriptionally regulating HJURP and participates in the progress of oral squamous cell carcinoma.1
378487562023NFE2L1 restrains ferroptosis by transcriptionally regulating HJURP and participates in the progress of oral squamous cell carcinoma.1
351032862022Holliday junction recognition protein as a prognostic biomarker and therapeutic target for oral cancer.3
354592692022HJURP regulates cell proliferation and chemo-resistance via YAP1/NDRG1 transcriptional axis in triple-negative breast cancer.12
359409432022HJURP inhibits proliferation of ovarian cancer cells by regulating CENP-A/CENP-N.3
351032862022Holliday junction recognition protein as a prognostic biomarker and therapeutic target for oral cancer.3
354592692022HJURP regulates cell proliferation and chemo-resistance via YAP1/NDRG1 transcriptional axis in triple-negative breast cancer.12
359409432022HJURP inhibits proliferation of ovarian cancer cells by regulating CENP-A/CENP-N.3
340996342021HJURP promotes proliferation in prostate cancer cells through increasing CDKN1A degradation via the GSK3β/JNK signaling pathway.12
341198272021Hypomethylation-driven overexpression of HJURP promotes progression of hepatocellular carcinoma and is associated with poor prognosis.8
342179932021HJURP is a prognostic biomarker for clear cell renal cell carcinoma and is linked to immune infiltration.11

Citation

Dessen P

HJURP (Holliday junction recognition protein)

Atlas Genet Cytogenet Oncol Haematol. 2007-11-01

Online version: http://atlasgeneticsoncology.org/gene/49810/teaching-explorer/cancer-prone-explorer/