B4GALT5 (beta-1,4-galactosyltransferase 5)

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B4GALT5 (beta-1,4-galactosyltransferase 5)

2007-11-01 Affiliation

Identity

HGNC

LOCATION

20q13.13

LOCUSID

ALIAS

B4Gal-T5,BETA4-GALT-IV,beta4Gal-T5,beta4GalT-V,gt-V

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9334
MIM: 604016
HGNC: 928
Ensembl: ENSG00000158470

Variants:

dbSNP: 9334
ClinVar: 9334
TCGA: ENSG00000158470
COSMIC: B4GALT5

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000158470	ENST00000371711	O43286

Expression (GTEx)

0

10

20

30

40

50

60

70

80

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Mucin type O-glycan biosynthesis	KEGG	ko00512
Mucin type O-glycan biosynthesis	KEGG	hsa00512
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Asparagine N-linked glycosylation	REACTOME	R-HSA-446203
Transport to the Golgi and subsequent modification	REACTOME	R-HSA-948021
N-glycan antennae elongation in the medial/trans-Golgi	REACTOME	R-HSA-975576
N-Glycan antennae elongation	REACTOME	R-HSA-975577
O-linked glycosylation	REACTOME	R-HSA-5173105
O-linked glycosylation of mucins	REACTOME	R-HSA-913709
Metabolism	REACTOME	R-HSA-1430728
Metabolism of carbohydrates	REACTOME	R-HSA-71387
Glycosaminoglycan metabolism	REACTOME	R-HSA-1630316
Keratan sulfate/keratin metabolism	REACTOME	R-HSA-1638074
Keratan sulfate biosynthesis	REACTOME	R-HSA-2022854

References

Pubmed ID	Year	Title	Citations
34709725	2022	Circ_0009910 sponges miR-491-5p to promote acute myeloid leukemia progression through modulating B4GALT5 expression and PI3K/AKT signaling pathway.	9
34709725	2022	Circ_0009910 sponges miR-491-5p to promote acute myeloid leukemia progression through modulating B4GALT5 expression and PI3K/AKT signaling pathway.	9
30502090	2019	Lactosylceramide synthase β-1,4-GalT-V: A novel target for the diagnosis and therapy of human colorectal cancer.	14
30607818	2019	Hsc70 Interacts with β4GalT5 to Regulate the Growth of Gliomas.	5
30502090	2019	Lactosylceramide synthase β-1,4-GalT-V: A novel target for the diagnosis and therapy of human colorectal cancer.	14
30607818	2019	Hsc70 Interacts with β4GalT5 to Regulate the Growth of Gliomas.	5
29415997	2018	Downregulation of β1,4-galactosyltransferase 5 improves insulin resistance by promoting adipocyte commitment and reducing inflammation.	10
29415997	2018	Downregulation of β1,4-galactosyltransferase 5 improves insulin resistance by promoting adipocyte commitment and reducing inflammation.	10
23744354	2013	B4GALT family mediates the multidrug resistance of human leukemia cells by regulating the hedgehog pathway and the expression of p-glycoprotein and multidrug resistance-associated protein 1.	41
23744354	2013	B4GALT family mediates the multidrug resistance of human leukemia cells by regulating the hedgehog pathway and the expression of p-glycoprotein and multidrug resistance-associated protein 1.	41
22687727	2012	[Regulation of human β-1,4-galactosyltransferase V gene expression in cancer cells].	1
22687727	2012	[Regulation of human β-1,4-galactosyltransferase V gene expression in cancer cells].	1
20417617	2010	Beta1,4-galactosyltransferase V regulates self-renewal of glioma-initiating cell.	9
20417617	2010	Beta1,4-galactosyltransferase V regulates self-renewal of glioma-initiating cell.	9
17656364	2007	Sequential action of Ets-1 and Sp1 in the activation of the human beta-1,4-galactosyltransferase V gene involved in abnormal glycosylation characteristic of cancer cells.	15

Citation

Dessen P

B4GALT5 (beta-1,4-galactosyltransferase 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-11-01

Online version: http://atlasgeneticsoncology.org/gene/49822/meetings/favicon/js/lib/popper.js