RAMP2 (receptor activity modifying protein 2)

2007-11-01 Affiliation

Identity

HGNC

RAMP2

LOCATION

17q21.2

LOCUSID

10266

ALIAS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10266
MIM: 605154
HGNC: 9844
Ensembl: ENSG00000131477

Variants:

dbSNP: 10266
ClinVar: 10266
TCGA: ENSG00000131477
COSMIC: RAMP2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000131477	ENST00000253796	O60895
ENSG00000131477	ENST00000253796	A0A024R1Z2
ENSG00000131477	ENST00000587142	O60895
ENSG00000131477	ENST00000588576	K7EKQ3
ENSG00000131477	ENST00000588928	K7ENJ8
ENSG00000131477	ENST00000589683	K7EPN3

Expression (GTEx)

100

150

200

250

300

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Vascular smooth muscle contraction	KEGG	hsa04270
Vascular smooth muscle contraction	KEGG	ko04270
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class B/2 (Secretin family receptors)	REACTOME	R-HSA-373080
Calcitonin-like ligand receptors	REACTOME	R-HSA-419812
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (s) signalling events	REACTOME	R-HSA-418555

References

Pubmed ID	Year	Title	Citations
38279501	2023	RAMP2-AS1 stabilized RAPM2 mRNA through TIA1 to inhibit the progression of non-small cell lung cancer.	0
38279501	2023	RAMP2-AS1 stabilized RAPM2 mRNA through TIA1 to inhibit the progression of non-small cell lung cancer.	0
33385343	2021	Adrenomedullin-Receptor Activity-Modifying Protein 2 System Ameliorates Subretinal Fibrosis by Suppressing Epithelial-Mesenchymal Transition in Age-Related Macular Degeneration.	3
34271220	2021	Receptor Activity-Modifying Protein 2 (RAMP2) alters glucagon receptor trafficking in hepatocytes with functional effects on receptor signalling.	14
33385343	2021	Adrenomedullin-Receptor Activity-Modifying Protein 2 System Ameliorates Subretinal Fibrosis by Suppressing Epithelial-Mesenchymal Transition in Age-Related Macular Degeneration.	3
34271220	2021	Receptor Activity-Modifying Protein 2 (RAMP2) alters glucagon receptor trafficking in hepatocytes with functional effects on receptor signalling.	14
30826286	2019	Interactions between RAMP2 and CRF receptors: The effect of receptor subtypes, splice variants and cell context.	11
31150417	2019	Development of chimeric and bifunctional antagonists for CLR/RAMP receptors.	9
30826286	2019	Interactions between RAMP2 and CRF receptors: The effect of receptor subtypes, splice variants and cell context.	11
31150417	2019	Development of chimeric and bifunctional antagonists for CLR/RAMP receptors.	9
28586439	2017	RAMP2 Influences Glucagon Receptor Pharmacology via Trafficking and Signaling.	18
28614667	2017	N-Glycosylation of Asparagine 130 in the Extracellular Domain of the Human Calcitonin Receptor Significantly Increases Peptide Hormone Affinity.	11
28904253	2017	Genetic Variants of RAMP2 and CLR are Associated with Stroke.	9
28586439	2017	RAMP2 Influences Glucagon Receptor Pharmacology via Trafficking and Signaling.	18
28614667	2017	N-Glycosylation of Asparagine 130 in the Extracellular Domain of the Human Calcitonin Receptor Significantly Increases Peptide Hormone Affinity.	11

Citation

Dessen P

RAMP2 (receptor activity modifying protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-11-01

Online version: http://atlasgeneticsoncology.org/gene/49831