TUBB2B (tubulin beta 2B class IIb)

2007-12-01 Affiliation

Identity

HGNC

TUBB2B

LOCATION

6p25.2

LOCUSID

347733

ALIAS

CDCBM7,PMGYSA,bA506K6.1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 347733
MIM: 612850
HGNC: 30829
Ensembl: ENSG00000137285

Variants:

dbSNP: 347733
ClinVar: 347733
TCGA: ENSG00000137285
COSMIC: TUBB2B

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000137285	ENST00000259818	Q9BVA1
ENSG00000137285	ENST00000259818	A0A384MEE3

Expression (GTEx)

100

150

200

250

300

350

400

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Gap junction	KEGG	ko04540
Pathogenic Escherichia coli infection	KEGG	ko05130
Gap junction	KEGG	hsa04540
Pathogenic Escherichia coli infection	KEGG	hsa05130
Phagosome	KEGG	ko04145
Phagosome	KEGG	hsa04145
Metabolism of proteins	REACTOME	R-HSA-392499
Protein folding	REACTOME	R-HSA-391251
Chaperonin-mediated protein folding	REACTOME	R-HSA-390466
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	REACTOME	R-HSA-389958
Prefoldin mediated transfer of substrate to CCT/TriC	REACTOME	R-HSA-389957
Formation of tubulin folding intermediates by CCT/TriC	REACTOME	R-HSA-389960
Post-chaperonin tubulin folding pathway	REACTOME	R-HSA-389977

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
36872411	2023	TUBB2B facilitates progression of hepatocellular carcinoma by regulating cholesterol metabolism through targeting HNF4A/CYP27A1.	1
36872411	2023	TUBB2B facilitates progression of hepatocellular carcinoma by regulating cholesterol metabolism through targeting HNF4A/CYP27A1.	1
33734457	2021	Periprostatic adipose tissue promotes prostate cancer resistance to docetaxel by paracrine IGF-1 upregulation of TUBB2B beta-tubulin isoform.	24
34592644	2021	A novel family illustrating the mild phenotypic spectrum of TUBB2B variants.	1
33734457	2021	Periprostatic adipose tissue promotes prostate cancer resistance to docetaxel by paracrine IGF-1 upregulation of TUBB2B beta-tubulin isoform.	24
34592644	2021	A novel family illustrating the mild phenotypic spectrum of TUBB2B variants.	1
30621030	2019	Over-Expression of βII-Tubulin and Especially Its Localization in Cell Nuclei Correlates with Poorer Outcomes in Colorectal Cancer.	10
31432180	2019	Upregulation of MAPK10, TUBB2B and RASL11B may contribute to the development of neuroblastoma.	4
30621030	2019	Over-Expression of βII-Tubulin and Especially Its Localization in Cell Nuclei Correlates with Poorer Outcomes in Colorectal Cancer.	10
31432180	2019	Upregulation of MAPK10, TUBB2B and RASL11B may contribute to the development of neuroblastoma.	4
28013290	2017	Uner Tan syndrome caused by a homozygous TUBB2B mutation affecting microtubule stability.	6
28013290	2017	Uner Tan syndrome caused by a homozygous TUBB2B mutation affecting microtubule stability.	6
26732629	2016	De novo TUBB2B mutation causes fetal akinesia deformation sequence with microlissencephaly: An unusual presentation of tubulinopathy.	6
27306797	2016	Molecular basis for CPAP-tubulin interaction in controlling centriolar and ciliary length.	34
26732629	2016	De novo TUBB2B mutation causes fetal akinesia deformation sequence with microlissencephaly: An unusual presentation of tubulinopathy.	6

Citation

Dessen P

TUBB2B (tubulin beta 2B class IIb)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49846/css/cancer-prone-explorer/