ARHGDIB (Rho GDP dissociation inhibitor beta)

2007-12-01  

Identity

HGNC
ARHGDIB
LOCATION
12p12.3
LOCUSID
397
ALIAS
D4,GDIA2,GDID4,LYGDI,Ly-GDI,RAP1GN1,RhoGDI2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 397
MIM: 602843
HGNC: 679
Ensembl: ENSG00000111348

Variants:

dbSNP: 397
ClinVar: 397
TCGA: ENSG00000111348
COSMIC: ARHGDIB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111348ENST00000228945P52566
ENSG00000111348ENST00000228945A0A024RAS5
ENSG00000111348ENST00000536592H0YGX7
ENSG00000111348ENST00000541380F5H6Q0
ENSG00000111348ENST00000541546P52566
ENSG00000111348ENST00000541546A0A024RAS5
ENSG00000111348ENST00000541644P52566
ENSG00000111348ENST00000541644A0A024RAS5
ENSG00000111348ENST00000542276F5H2R5
ENSG00000111348ENST00000545895F5H3P3

Expression (GTEx)

0
500
1000
1500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neurotrophin signaling pathwayKEGGko04722
Neurotrophin signaling pathwayKEGGhsa04722
Vasopressin-regulated water reabsorptionKEGGko04962
Vasopressin-regulated water reabsorptionKEGGhsa04962
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383346642024Hyperglycemic Stress Induces Expression, Degradation, and Nuclear Association of Rho GDP Dissociation Inhibitor 2 (RhoGDIβ) in Pancreatic β-Cells.0
383763442024RhoGDIβ inhibition via miR-200c/AUF1/SOX2/miR-137 axis contributed to lncRNA MEG3 downregulation-mediated malignant transformation of human bronchial epithelial cells.0
383346642024Hyperglycemic Stress Induces Expression, Degradation, and Nuclear Association of Rho GDP Dissociation Inhibitor 2 (RhoGDIβ) in Pancreatic β-Cells.0
383763442024RhoGDIβ inhibition via miR-200c/AUF1/SOX2/miR-137 axis contributed to lncRNA MEG3 downregulation-mediated malignant transformation of human bronchial epithelial cells.0
344376332021CRIF1 deficiency suppresses endothelial cell migration via upregulation of RhoGDI2.3
344376332021CRIF1 deficiency suppresses endothelial cell migration via upregulation of RhoGDI2.3
316517162020Antibodies Against ARHGDIB and ARHGDIB Gene Expression Associate With Kidney Allograft Outcome.17
321766262020Systematic investigation of biomarker-like role of ARHGDIB in breast cancer.8
328608482020Knockdown of RhoGDI2 represses human gastric cancer cell proliferation, invasion and drug resistance via the Rac1/Pak1/LIMK1 pathway.0
316517162020Antibodies Against ARHGDIB and ARHGDIB Gene Expression Associate With Kidney Allograft Outcome.17
321766262020Systematic investigation of biomarker-like role of ARHGDIB in breast cancer.8
328608482020Knockdown of RhoGDI2 represses human gastric cancer cell proliferation, invasion and drug resistance via the Rac1/Pak1/LIMK1 pathway.0
310751852019RhoGDI2 positively regulates the Rho GTPases activation in response to the β2 outside-in signaling in T cells adhesion and migration on ICAM-1.5
310751852019RhoGDI2 positively regulates the Rho GTPases activation in response to the β2 outside-in signaling in T cells adhesion and migration on ICAM-1.5
293615402018Unconventional myosin VIIA promotes melanoma progression.7

Citation

Dessen P

ARHGDIB (Rho GDP dissociation inhibitor beta)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49851