C4BPA (complement component 4 binding protein alpha)

2007-12-01  

Identity

HGNC
LOCATION
1q32.2
LOCUSID
ALIAS
C4BP,PRP
FUSION GENES

Other Information

Locus ID:

NCBI: 722
MIM: 120830
HGNC: 1325
Ensembl: ENSG00000123838

Variants:

dbSNP: 722
ClinVar: 722
TCGA: ENSG00000123838
COSMIC: C4BPA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000123838ENST00000367070P04003
ENSG00000123838ENST00000421786A6PVY5
ENSG00000123838ENST00000424088F2Z2V7

Expression (GTEx)

0
50
100
150
200
250
300
350
400

Pathways

PathwaySourceExternal ID
Complement and coagulation cascadesKEGGko04610
Complement and coagulation cascadesKEGGhsa04610
PertussisKEGGko05133
PertussisKEGGhsa05133
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Complement cascadeREACTOMER-HSA-166658
Regulation of Complement cascadeREACTOMER-HSA-977606

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
382612502024The Complement System and C4b-Binding Protein: A Focus on the Promise of C4BPα as a Biomarker to Predict Clopidogrel Resistance.0
382612502024The Complement System and C4b-Binding Protein: A Focus on the Promise of C4BPα as a Biomarker to Predict Clopidogrel Resistance.0
373765692023Complement Activation-Independent Attenuation of SARS-CoV-2 Infection by C1q and C4b-Binding Protein.3
373765692023Complement Activation-Independent Attenuation of SARS-CoV-2 Infection by C1q and C4b-Binding Protein.3
355477342022The Hidden Side of Complement Regulator C4BP: Dissection and Evaluation of Its Immunomodulatory Activity.6
357331782022Potential biomarkers of spinal dural arteriovenous fistula: C4BPA and C1QA.3
355477342022The Hidden Side of Complement Regulator C4BP: Dissection and Evaluation of Its Immunomodulatory Activity.6
357331782022Potential biomarkers of spinal dural arteriovenous fistula: C4BPA and C1QA.3
301694152021Observation of Complement Protein Gene Expression Before and After Surgery in Opioid-Consuming and Opioid-Naive Patients.1
341675732021C4b-binding protein α-chain enhances antitumor immunity by facilitating the accumulation of tumor-infiltrating lymphocytes in the tumor microenvironment in pancreatic cancer.10
341906902021Immunoexpression of C4 Binding Protein in Oral Leukoplakia and Oral Squamous Cell Carcinoma.0
301694152021Observation of Complement Protein Gene Expression Before and After Surgery in Opioid-Consuming and Opioid-Naive Patients.1
341675732021C4b-binding protein α-chain enhances antitumor immunity by facilitating the accumulation of tumor-infiltrating lymphocytes in the tumor microenvironment in pancreatic cancer.10
341906902021Immunoexpression of C4 Binding Protein in Oral Leukoplakia and Oral Squamous Cell Carcinoma.0
303230302019The Pneumococcal Surface Proteins PspA and PspC Sequester Host C4-Binding Protein To Inactivate Complement C4b on the Bacterial Surface.19

Citation

Dessen P

C4BPA (complement component 4 binding protein alpha)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49852/c4bpa