MAL2 (mal, T cell differentiation protein 2)

MAL2 (mal, T cell differentiation protein 2)

2007-12-01 Affiliation

Identity

HGNC

LOCATION

8q24.12

LOCUSID

ALIAS

-

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 114569
MIM: 609684
HGNC: 13634
Ensembl: ENSG00000147676

Variants:

dbSNP: 114569
ClinVar: 114569
TCGA: ENSG00000147676
COSMIC: MAL2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000147676	ENST00000522112	A0A087WZL1
ENSG00000147676	ENST00000531508	A0A087WZL1
ENSG00000147676	ENST00000534619	A0A087WZL1
ENSG00000147676	ENST00000614891	Q969L2
ENSG00000147676	ENST00000614891	A0A024R9E4

Expression (GTEx)

0

50

100

150

200

250

300

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
36938678	2023	LINC00460 Facilitates Cell Proliferation and Inhibits Ferroptosis in Breast Cancer Through the miR-320a/MAL2 Axis.	6
36938678	2023	LINC00460 Facilitates Cell Proliferation and Inhibits Ferroptosis in Breast Cancer Through the miR-320a/MAL2 Axis.	6
35033901	2022	The novel circ_0084904/miR-802/MAL2 axis promotes the development of cervical cancer.	6
35033901	2022	The novel circ_0084904/miR-802/MAL2 axis promotes the development of cervical cancer.	6
32990678	2021	MAL2 drives immune evasion in breast cancer by suppressing tumor antigen presentation.	57
33780861	2021	MAL2 interacts with IQGAP1 to promote pancreatic cancer progression by increasing ERK1/2 phosphorylation.	12
32990678	2021	MAL2 drives immune evasion in breast cancer by suppressing tumor antigen presentation.	57
33780861	2021	MAL2 interacts with IQGAP1 to promote pancreatic cancer progression by increasing ERK1/2 phosphorylation.	12
31397491	2020	RP11-284F21.9 promotes oral squamous cell carcinoma development via the miR-383-5p/MAL2 axis.	12
31397491	2020	RP11-284F21.9 promotes oral squamous cell carcinoma development via the miR-383-5p/MAL2 axis.	12
30021343	2018	MiR-129 regulates growth and invasion by targeting MAL2 in papillary thyroid carcinoma.	16
30195491	2018	MAL2 promotes proliferation, migration, and invasion through regulating epithelial-mesenchymal transition in breast cancer cell lines.	25
30021343	2018	MiR-129 regulates growth and invasion by targeting MAL2 in papillary thyroid carcinoma.	16
30195491	2018	MAL2 promotes proliferation, migration, and invasion through regulating epithelial-mesenchymal transition in breast cancer cell lines.	25
28562687	2017	The four-transmembrane protein MAL2 and tumor protein D52 (TPD52) are highly expressed in colorectal cancer and correlated with poor prognosis.	27

Citation

Dessen P

MAL2 (mal, T cell differentiation protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49874/case-report-explorer/js/_common.js